Cisco's stock price touched $80.25 on Wednesday, finally eclipsing its dotcom-era peak of $80.06 set on March 27, 2000 -- when the networking giant briefly surpassed Microsoft to become the world's most valuable company. The journey back took 25 years, eight months and 13 days. The company's fundamentals improved dramatically over that period, of course. Revenues have nearly quintupled since 1999, profits have quadrupled, earnings per share have grown eightfold, and margins have remained healthy throughout. Investors who bought at the peak still lost money to inflation for a generation.

Cisco's trajectory draws obvious comparisons to Nvidia, today's dominant "picks and shovels" supplier for the AI boom. Nvidia trades at a price-to-earnings ratio above 45 and an enterprise value-to-sales ratio near 24. At its 2000 peak, Cisco traded at a P/E above 200 and EV/sales of 31.

As the battle over Warner Bros. Discovery grows, two Democratic lawmakers are warning that their party may try to block or unravel any acquisition by Paramount when it returns to power. Semafor: In a letter to the WBD board and Treasury Secretary Scott Bessent first shared with Semafor, Reps. Sam Liccardo (D-Calif.) and Ayanna Pressley (D-Mass.) said they were concerned about the national security risk of letting foreign entities control a large portion of the US entertainment and media industry.

They also hinted that a future Democratic Congress and administration could try to unravel any Paramount-WBD deal. "Future Congresses ... will review many of the decisions of the current Administration, and may recommend that regulators push for divestitures, which would undermine the strategic logic of this merger," they wrote. "We urge the Board to weigh these national security and regulatory liabilities in evaluating a transaction burdened by uncertain but potentially extensive mitigation obligations, foreign influence risks, or adverse regulatory action."

Pinduoduo in China, Shopee in Southeast Asia, and Meesho in India operate in markets that could hardly be more different -- an upper-middle-income industrial state, a stitched-together archipelago of under-banked economies, and a country where three-quarters of retail is unorganized and e-commerce penetration sits at about 7% -- yet all three have landed on the same business model.

These platforms run asset-light marketplaces specializing in cheap goods and slow delivery, monetizing through logistics mark-ups, advertising, and installment credit rather than retail margins. Temu and Shein are further variations now expanding in the U.S. and Europe.

The economics are thin for all. Pinduoduo's EBITDA margins on GMV (gross merchandise value) sit in a 0-4% band; Meesho's group-wide EBITDA hovers around break-even. Neither charges commissions on most sales; both earn through logistics mark-ups and advertising. Sponsored listings account for 1-3% of GMV at Indian marketplaces and 4-5% at Alibaba and Pinduoduo.

Credit is the more consequential side business. In India, cash on delivery functions as unofficial credit. Meesho CEO Vidit Aatrey said the customers prefer CoD for its "built-in delay," which effectively makes it "a five-day loan." Geography, income, and regulation were supposed to produce different answers. They produced one: a 3% endgame where e-commerce clips a few points of GMV and relies on attention and credit for profits.

In February, a six-month-old baby named KJ Muldoon became the first person ever to receive a CRISPR gene-editing treatment customized specifically for his unique genetic mutation, a milestone that researchers say marks a turning point in how medicine might approach the thousands of rare diseases that collectively affect 30 million Americans. Muldoon was born with a type of urea-cycle disorder that gives patients roughly a 50% chance of surviving infancy and typically requires a liver transplant; he is now a healthy 1-year-old who recently took his first steps.

The treatment's significance extends beyond one child. Scientists at UC Berkeley's Innovative Genomics Institute and the Children's Hospital of Philadelphia are now planning clinical trials that would use Muldoon's therapy as a template, tweaking the molecular "address" in the CRISPR system to target different mutations in other children with urea-cycle disorders. Last month, FDA officials Marty Makary and Vinay Prasad announced a new drug pathway designed to accelerate approvals for such personalized treatments -- a framework inspired in large part by Muldoon's case. Current gene-editing delivery mechanisms limit treatments to disorders in the blood and liver. Many families will still go without bespoke therapies.

A tenured USC professor is arguing that universities need to fundamentally rethink their value proposition as AI rapidly closes the gap on human instruction and a loneliness epidemic grips the generation most likely to be sitting in their lecture halls. Eric Anicich, an associate professor at USC's Marshall School of Business, wrote in the Los Angeles Times that nearly three-quarters of 16- to 24-year-olds now report feeling lonely, young adults spend 70% less time with friends in person compared to two decades ago, and a growing majority of Gen Z college graduates say their degree was a "waste of money."

Anicich points to a recent Harvard study finding that students using an AI tutor learned more than twice as much as those in traditional active-learning classes, and did so in less time. The implication is stark: if instruction becomes abundant and cheap, colleges must sell what remains scarce -- genuine human community. He notes that his doctoral training included zero coursework on teaching, a norm he says persists across academia. His proposal: fund student life as seriously as research labs, hire professional "experience designers," and treat rituals and collaborative projects as core curriculum rather than amenities.

An anonymous reader quotes a report from the Guardian: The journal Regulatory Toxicology and Pharmacology has formally retracted a sweeping scientific paper published in 2000 that became a key defense for Monsanto's claim that Roundup herbicide and its active ingredient glyphosate don't cause cancer. Martin van den Berg, the journal's editor in chief, said in a note accompanying the retraction that he had taken the step because of "serious ethical concerns regarding the independence and accountability of the authors of this article and the academic integrity of the carcinogenicity studies presented."

The paper, titled Safety Evaluation and Risk Assessment of the Herbicide Roundup and Its Active Ingredient, Glyphosate, for Humans, concluded that Monsanto's glyphosate-based weed killers posed no health risks to humans -- no cancer risks, no reproductive risks, no adverse effects on development of endocrine systems in people or animals. Regulators around the world have cited the paper as evidence of the safety of glyphosate herbicides, including the Environmental Protection Agency (EPA) in this assessment (PDF). [...]

In explaining the decision to retract the 25-year-old research paper, Van den Berg wrote: "Concerns were raised regarding the authorship of this paper, validity of the research findings in the context of misrepresentation of the contributions by the authors and the study sponsor and potential conflicts of interest of the authors." He noted that the paper's conclusions regarding the carcinogenicity of glyphosate were solely based on unpublished studies from Monsanto, ignoring other outside, published research. "The retraction of this study is a long time coming," said Brent Wisner, one of the lead lawyers in the Roundup litigation and a key player in getting the internal documents revealed to the public. Wisner said the study was the "quintessential example of how companies like Monsanto could fundamentally undermine the peer-review process through ghostwriting, cherrypicking unpublished studies, and biased interpretations."

"This garbage ghostwritten study finally got the fate it deserved,â Wisner added. "Hopefully, journals will now be more vigilant in protecting the impartiality of science on which so many people depend."

Researchers and moderators are increasingly concerned that ChatGPT-style language is bleeding into everyday speech and writing. The topic has been explored in the past but "two new, more anecdotal reports, suggest that our chatbot dialect isn't just something that can be found through close analysis of data," reports Gizmodo. "It might be an obvious, every day fact of life now." Slashdot reader joshuark shares an excerpt from the report: Over on Reddit, according to a new Wired story by Kat Tenbarge, moderators of certain subreddits are complaining about AI posts ruining their online communities. It's not new to observe that AI-armed spammers post low-value engagement bait on social media, but these are spaces like r/AmItheAsshole, r/AmIOverreacting, and r/AmITheDevil, where visitors crave the scintillation or outright titillation of bona fide human misbehavior. If, behind the scenes, there's not really a grieving college student having her tuition cut off for randomly flying off the handle at her stepmom, there's no real fun to be had. The mods in the Wired story explain how they detect AI content, and unfortunately their methods boil down to "It's vibes." But one novel struggle in the war against slop, the mods say, is that not only are human-written posts sometimes rewritten by AI, but mods are concerned that humans are now writing like AI. Humans are becoming flesh and blood AI-text generators, muddying the waters of AI "detection" to the point of total opacity.

As "Cassie" an r/AmItheAsshole moderator who only gave Wired her first name put it, "AI is trained off people, and people copy what they see other people doing." In other words, Cassie said, "People become more like AI, and AI becomes more like people." Meanwhile, essayist Sam Kriss just explored the weird way chatbots "write" for the latest issue of the New York Times Magazine, and he discovered along the way that humans have accidentally taken cues from that weirdness. After parsing chatbots' strange tics and tendencies -- such as overusing the word "delve" most likely because it's in a disproportional number of texts from Nigeria, where that word is popular -- Kriss refers to a previously reported trend from over the summer. Members of the U.K. Parliament were accused of using ChatGPT to write their speeches.

The thinking goes that ChatGPT-written speeches contained the phrase "I rise to speak," an American phrase, used by American legislators. But Kriss notes that it's not just showing up from time to time. It's being used with downright breathtaking frequency. "On a single day this June, it happened 26 times," he notes. While 26 different MPs using ChatGPT to write speeches is not some scientific impossibility, it's more likely an example of chatbots, "smuggling cultural practices into places they don't belong," to quote Kriss again. So when Kriss points out that when Starbucks locations were closing in September, and signs posted on the doors contained tortured sentences like, "It's your coffeehouse, a place woven into your daily rhythm, where memories were made, and where meaningful connections with our partners grew over the years," one can't state with certainty that this is AI-generated text (although let's be honest: it probably is).

Denmark's postal service, established by King Christian IV four centuries ago as one of Europe's first modern mail systems, will stop delivering letters on December 30, ending a tradition that once saw riders given a maximum of 45 minutes to cover each 10-kilometer stretch of routes running from Hamburg to Norway.

PostNord, the postal service Denmark has shared with Sweden since 2009, started removing its 1,500 remaining red post boxes in June; a handful will go to museums. Letter volumes collapsed from nearly 1.5 billion in 2000 to 110 million last year. A standard stamp now costs 29 Danish kroner ($4.52). A private logistics firm called DAO will take over letter delivery. PostNord will continue handling parcels. The decision has rattled postal services elsewhere in Europe. Deutsche Post in Germany, still delivering 61 million letters daily, has warned it faces the same trends.

Dollar General and Family Dollar stores have collectively failed more than 6,400 government price-accuracy inspections since January 2022, charging customers more at checkout than the prices displayed on shelves for everything from frozen pizzas to puppy food, according to an investigation by the Guardian. The review examined records from 45 states and more than 140 counties and cities. Dollar General stores failed over 4,300 inspections across 23 states, and Family Dollar failed more than 2,100 in 20 states. Error rates at the worst-performing locations reached staggering levels -- 76% at a Dollar General in Hamilton, Ohio and 68% at a Family Dollar in Bound Brook, New Jersey. A Family Dollar in Provo, Utah failed 28 consecutive inspections.

Industry watchers, employees and lawsuits attribute the discrepancies to minimal staffing. Registers update automatically when prices change, but shelf labels require manual replacement, and workers often lack the time. State attorneys general have pursued settlements -- Arizona reached a $600,000 deal with Family Dollar in May, Colorado settled with Dollar General for $400,000 in October and Ohio secured $1 million from Dollar General after finding error rates as high as 88%. Both companies declined interview requests but said they remain committed to pricing accuracy.

An anonymous reader quotes a report from the New York Times: A few years ago, Paul Wieland, a 44-year-old information technology professional living in New York's Adirondack Mountains, was wrapping up a home renovation when he ran into a hiccup. He wanted to be able to control his new garage door with his smartphone. But the options available, including a product called MyQ, required connecting to a company's internet servers. He believed a "smart" garage door should operate only over a local Wi-Fi network to protect a home's privacy, so he started building his own system to plug into his garage door. By 2022, he had developed a prototype, which he named RATGDO, for Rage Against the Garage Door Opener. He had hoped to sell 100 of his new gadgets just to recoup expenses, but he ended up selling tens of thousands. That's because MyQ's maker did what a number of other consumer device manufacturers have done over the last few years, much to the frustration of their customers: It changed the device, making it both less useful and more expensive to operate.

Chamberlain Group, a company that makes garage door openers, had created the MyQ hubs so that virtually any garage door opener could be controlled with home automation software from Apple, Google, Nest and others. Chamberlain also offered a free MyQ smartphone app. Two years ago, Chamberlain started shutting down support for most third-party access to its MyQ servers. The company said it was trying to improve the reliability of its products. But this effectively broke connections that people had set up to work with Apple's Home app or Google's Home app, among others. Chamberlain also started working with partners that charge subscriptions for their services, though a basic app to control garage doors was still free.

While Mr. Wieland said RATGDO sales spiked after Chamberlain made those changes, he believes the popularity of his device is about more than just opening and closing a garage. It stems from widespread frustration with companies that sell internet-connected hardware that they eventually change or use to nickel-and-dime customers with subscription fees. "You should own the hardware, and there is a line there that a lot of companies are experimenting with," Mr. Wieland said in a recent interview. "I'm really afraid for the future that consumers are going to swallow this and that's going to become the norm." [...] For Mr. Wieland, the fight isn't over. He started a company named RATCLOUD, for Rage Against the Cloud. He said he was developing similar products that were not yet for sale.

Bruce66423 shares a report from the Los Angeles Times: Tattoo ink doesn't just sit inertly in the skin. New research shows it moves rapidly into the lymphatic system, where it can persist for months, kill immune cells, and even disrupt how the body responds to vaccines. Scientists in Switzerland used a mouse model to trace what happens after tattooing. Pigments drained into nearby lymph nodes within minutes and continued to accumulate for two months, triggering immune-cell death and sustained inflammation. The ink also weakened the antibody response to Pfizer Inc. and BioNTech SE's COVID vaccine when the shot was administered in tattooed skin. In contrast, the same inflammation appeared to boost responses to an inactivated flu vaccine. "This work represents the most extensive study to date regarding the effect of tattoo ink on the immune response and raises serious health concerns associated with the tattooing practice," the researchers said. "Our work underscores the need for further research to inform public health policies and regulatory frameworks regarding the safety of tattoo inks."

The findings have been published in the journal Proceedings of the National Academy of Sciences.