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Science

Ageing Accelerates at Around Age 50 - Some Organs Faster Than Others (nature.com) 57

A new analysis of protein changes across human tissues has identified an aging acceleration point around age 50, with blood vessels showing the most dramatic deterioration. Researchers examined tissue samples from eight body systems in 76 people of Chinese ancestry aged 14 to 68 who died from accidental brain injury, finding age-related increases in 48 disease-associated proteins.

Between ages 45 and 55, the most significant shift occurred in the aorta, the body's main artery carrying oxygenated blood from the heart. The team identified one aortic protein that triggers accelerated aging signs when administered to mice. Early aging changes appeared around age 30 in the adrenal gland, which produces various hormones. The study, published in Cell, adds to mounting evidence that aging occurs in waves rather than following a steady progression.
China

'Serious Delays' Hit Satellite Mega-Constellations of China's Starlink Rivals (scmp.com) 29

"A Chinese mega-constellation of communications satellites is facing serious delays," reports the South China Morning Post, "that could jeopardise its ambitions to compete with SpaceX's Starlink for valuable orbital resources." Only 90 satellites have been launched into low Earth orbit for the Qianfan broadband network — also known as the Thousand Sails Constellation or G60 Starlink — well short of the project's goal of 648 by the end of this year... Shanghai Yuanxin Satellite Technology, the company leading the project, plans to deploy more than 15,000 satellites by 2030 to deliver direct-to-phone internet services worldwide. To stay on track, Yuanxin — which is backed by the Shanghai municipal government — would have to launch more than 30 satellites a month to achieve its milestones of 648 by the end of 2025 for regional coverage and 1,296 two years later for global connectivity.
The New York Times reports that "the other megaconstellation, Guowang, is even farther behind. Despite plans to launch about 13,000 satellites within the next decade, it has 34 in orbit." A constellation has to launch half of its satellites within five years of successfully applying for its frequencies, and complete the full deployment within seven years, according to rules set by the International Telecommunication Union, a United Nations agency that allocates frequencies. The Chinese megaconstellations are behind on these goals. Companies that fail to hit their targets could be required to reduce the size of their megaconstellations.
Meanwhile SpaceX "has about 8,000 Starlink satellites in orbit and is expanding its lead every month," the Times writes, citing data from the U.S. Space Force and the nonprofit space-data group CelesTrak. (The Times has even created an animation showing Starlink's 8,000 satellites in orbit.) Researchers for the People's Liberation Army predict that the network will become "deeply embedded in the U.S. military combat system." They envision a time when Starlink satellites connect U.S. military bases and serve as an early missile-warning and interception network....

One of the major reasons for China's delay is the lack of a reliable, reusable launcher. Chinese companies still launch satellites using single-use rockets. After the satellites are deployed, rocket parts tumble back to Earth or become space debris... Six years after [SpaceX's] Falcon 9 began launching Starlink satellites, Chinese firms still have no answer to it... The government has tested nearly 20 rocket launchers in the "Long March" series.

Moon

Asteroid 2024 YR4 Spared The Earth. What Happens if It Hits the Moon Instead in 2032? (cnn.com) 22

Remember asteroid 2024 YR4 (which at one point had a 1 in 32 chance of hitting Earth, before ending up at "impact probability zero")? CNN reports that asteroid is now "zooming beyond the reach of telescopes on its orbit around the sun."

"But as scientists wait for it to reappear, its revised trajectory is now drawing attention to another possible target: the moon." The latest observations of the asteroid in early June, before YR4 disappeared from view, have improved astronomers' knowledge of where it will be in seven years by almost 20%, according to NASA. That data shows that even with Earth avoiding direct impact, YR4 could still pose a threat in late 2032 by slamming into the moon. ["The asteroid's probability of impacting the Moon has slightly increased from 3.8% to 4.3%," writes NASA, and "it would not alter the Moon's orbit."]
CNN calls the probabiliy "small but decent enough odds for scientists to consider how such a scenario might play out." The collision could create a bright flash that would be visible with the naked eye for several seconds, according to Wiegert, lead author of a recent paper submitted to the American Astronomical Society journals analyzing the potential lunar impact. The collision could create an impact crater on the moon estimated at 1 kilometer wide (0.6 miles wide), Wiegert said... It would be the largest impact on the moon in 5,000 years and could release up to 100 million kilograms (220 million pounds) of lunar rocks and dust, according to the modeling in Wiegert's study... Particles the size of large sand grains, ranging from 0.1 to 10 millimeters in size, of lunar material could reach Earth between a few days and a few months after the asteroid strike because they'll be traveling incredibly fast, creating an intense, eye-catching meteor shower, Wiegert said.

"There's absolutely no danger to anyone on the surface," Wiegert said. "We're not expecting large boulders or anything larger than maybe a sugar cube, and our atmosphere will protect us very nicely from that. But they're traveling faster than a speeding bullet, so if they were to hit a satellite, that could cause some damage...." Hundreds to thousands of impacts from millimeter-size debris could affect Earth's satellite fleet, meaning satellites could experience up to 10 years' equivalent of meteor debris exposure in a few days, Wiegert said... While a temporary loss of communication and navigation from satellites would create widespread difficulties on Earth, Wiegert said he believes the potential impact is something for satellite operators, rather than the public, to worry about.

"Any missions in low-Earth orbit could also be in the pathway of the debris, though the International Space Station is scheduled to be deorbited before any potential impact," reports CNN.

And they add that Wiegert also believes even small pieces of debris (tens of centimeters in size) "could present a hazard for any astronauts who may be present on the moon, or any structures they have built for research and habitation... The moon has no atmosphere, so the debris from the event could be widespread on the lunar surface, he added."
Science

Clean Cyclists Now Outperform Doped Champions of Tour de France's Past (theatlantic.com) 57

Current Tour de France competitors are faster than the sport's notorious doping-era champions, according to an analysis. Tadej Pogacar produced approximately 7 watts per kilogram for nearly 40 minutes during a crucial mountain stage in last year's Tour de France. Jonas Vingegaard, generated more than 7 watts per kilogram for nearly 15 minutes during a failed attack attempt. Lance Armstrong, at his blood-doped peak two decades ago, averaged an estimated 6 watts per kilogram and took nearly six minutes longer than Pogacar on the same Pyrenees climb in 2004.

The performance gains stem from multiple technological advances. Every rider now uses power meters that provide real-time performance data. Nutrition has shifted from minimal fueling to constant calorie replenishment with precisely measured food intake. Equipment undergoes extensive wind tunnel testing to reduce drag coefficients. Teams use apps like VeloViewer to preview race courses and weather forecasting to optimize wheel selection. "The bias is in favor of clean athletes: that you can be clean and win," said Travis Tygart, chief executive of the U.S. Anti-Doping Agency.
Science

Air Pollution Raises Risk of Dementia, Say Cambridge Scientists (theguardian.com) 34

Exposure to certain forms of air pollution is linked to an increased risk of developing dementia, according to the most comprehensive study of its kind. From a report: The illness is estimated to affect about 57 million people worldwide, with the number expected to increase to at least 150m cases by 2050. The report, which was produced by researchers at the Medical Research Council's epidemiology unit at the University of Cambridge involved a systematic review of 51 studies.

It drew on data from more than 29 million participants who had been exposed to air pollutants for at least a year. Although air pollution has already been identified as a risk factor for dementia, the research, which is the most comprehensive study of its kind to date, found there to be a positive and statistically-significant association between three types of air pollutant and dementia.

Japan

Tokyo Is Turning To a 4-Day Workweek To Shed 'World's Oldest Population' Title (yahoo.com) 77

An anonymous reader quotes a report from Fortune: Starting in April, the Tokyo Metropolitan government, one of the country's largest employers, is set to allow its employees to work only four days a week. It is also adding a new "childcare partial leave" policy, which will allow some employees to work two fewer hours per day. The goal is to help employees who are parents balance childcare and work, said Tokyo Gov. Yuriko Koike. "We will continue to review work styles flexibly to ensure that women do not have to sacrifice their careers due to life events such as childbirth or child-rearing," Koike said in a speech during the Tokyo Metropolitan Assembly's regular session, the Japan Times reported.

Moving to a four-day workweek could help address some of the core issues associated with Japan's heavy work culture, which can especially weigh on working women. The gap between men and women when it comes to housework is one of the largest among OECD countries, with women in Japan engaging in five times more unpaid work, such as childcare and elder care, than men, according to the International Monetary Fund. More than half of women who had fewer children than they would have preferred said they had fewer children because of the increased housework that another child would bring, according to the IMF. In some cases, moving to a four-day workweek has been shown to improve housework equity. Men reported spending 22% more time on childcare and 23% more time on housework during a four-day workweek trial conducted across six countries by 4 Day Week Global, which advocates for the issue.

It would take a major societal change for the four-day workweek to catch on more broadly, but years of experiments have shown that working one day less a week improves employee productivity and well-being, said Peter Miscovich, the global future of work leader at real estate services company JLL. "The upside from all of that has been less stress, less burnout, better rest, better sleep, less cost to the employee, higher levels of focus and concentration during the working hours, and in some cases, greater commitment to the organization as a result," Miscovich told Fortune.

Medicine

Pixel Watch 3 Gets FDA Clearance For Loss of Pulse Alerts 30

Google has received FDA clearance for the Pixel Watch 3's Loss of Pulse Detection feature, which will start rolling out to U.S. devices around the end of March. The Verge reports: The Loss of Pulse Detection feature is exactly what it sounds like: if the Pixel Watch 3 senses that you've lost your pulse through an event like a heart attack or an overdose, it'll send you a prompt. If you don't respond, it'll automatically call emergency services on your behalf. Back in August, Sandeep Waraich, Google's senior director of product manager for Pixel wearables, told The Verge that the Pixel Watch 3 is capable of differentiating between a genuine loss-of-pulse event and a person simply taking the watch off.

Submission + - HHS Secretary Robert F. Kennedy, Jr. Halts Clinical Trial of New Covid-19 Oral V (foxnews.com)

As_I_Please writes: From Fox News:

Kennedy issued a 90-day stop-work order on Friday related to the HHS (Health and Human Services) contract with American biotech company Vaxart Inc., which is working to develop a new COVID-19 vaccine that can be taken orally. The stop-work order comes as 10,000 individuals were slated to begin clinical trials on Monday.

As for the reason for the work stoppage, Secretary Kennedy explained:

"While it is crucial that the Department [of] Health and Human Services (HHS) support pandemic preparedness, four years of the Biden administrationâ(TM)s failed oversight have made it necessary to review agreements for vaccine production, including Vaxartâ(TM)s," Kennedy said in comments provided to Fox News Digital on Tuesday.

"I look forward to working with Vaxart and medical experts to ensure this work produces safe, effective, and fiscal-minded vaccine technology."


Comment Re: profits (Score 3, Interesting) 138

I have a nice fast computer that won't install W11. It functions as flawlessly as a Windows OS can, yet I'm supposed to abandon it. It'll be Linux soon.

You don't have to sail very far on the seven seas to find a non-TPM/Windows-10 solution. Why not install Windows 10 IoT Enterprise LTSC 2021? Activate it with this script.

Windows 10 IoT Enterprise LTSC 2021 will be supported almost another 10 years.

Comment The headline is wrong (Score 0) 108

The Atlantic got it wrong (and the Slashdot editor just went with it) but "C" is not the most important button. I don't know which button is, but the "1" button is more important that "C". A power cycle will substitute for a "C" button but you won't get far with a missing "1". "2". "3", "4", etc. are more important that "C" too.

Comment Re:Is it still a slow and unusable? (Score 4, Informative) 78

> There seems to be no option to completely disable update checking.

Maybe there is; one of the methods listed here may (still) work:

    https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fsupport.mozilla.org%2Fen-US%2Fquestions%2F1314978

I'm still blissfully running TB 102.15.1 (64-bit) with no upgrade nagging. "About Thunderbird" says "Updates disabled by your system administrator".

I just checked my TB distribution directory (Windows) and found a distribution directory with a policies.json file containing "DisableAppUpdate": true

Like you, I found the UI redesign terrible and am happy to wait for someone else to test version 128.

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