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Comment Re:Ford EV? (Score 1) 43

Reading the tea leaves, it sounded like the market for a full-size electric pickup is comprised of individuals who seemingly suffer from terminal range anxiety. So Ford is rumored to be relaunching the F-150, except on the new universal platform and also as an EREV - it's supposedly gonna have a generator on board.

I'm actually curious to see the Fathom when it comes out. I don't really need a full-size pickup, but owning a pickup would come in handy a few times a year (if you have to rent one and drive it more than 20-30 miles, you end up paying through the nose). I was originally thinking about the Lighning, but got a bit spooked by all the crap Trump's started pulling to attempt killing the EV market outright. Of course he shot himself in the foot with Iran not too long after, which seems to have changed some of these companies' minds again.

Comment Re: "On Planet Earth" (Score 4, Funny) 66

Must I remind you about the Slashdot Code of Conduct?

- Reading anything except the summary is against the rules and may result in a lifetime ban.

- Reading the full summary is frowned upon, but allowable. However posters are strongly encouraged to stop reading after the first two sentences.

- Responses which make it obvious the author only read the first half of the submission title should be modded "Insightful" if at all possible.

Submission + - This frog bacterium wiped out cancer tumors in mice with a single dose (sciencedaily.com)

Submitted by fahrbot-bot
fahrbot-bot writes: Science Daily has reported that scientists at the Japan Advanced Institute of Science and Technology (JAIST) have identified a naturally occurring bacterium from the intestines of Japanese tree frogs (Dryophytes japonicus) that demonstrated remarkable anticancer activity in mice. The findings, published in Gut Microbes, introduce a new approach to cancer treatment that uses living bacteria to directly target tumors rather than simply altering the gut microbiome.

In a mouse model of colorectal cancer, a single intravenous dose of E. americana completely eliminated tumors, producing a 100% complete response (CR) rate. The researchers emphasize that these findings are limited to mice, but they believe the results provide an encouraging proof of concept for developing new bacterial cancer therapies.

First, E. americana directly attacks tumors. As a facultative anaerobic bacterium, it thrives in both oxygen rich and oxygen poor environments, allowing it to multiply inside the oxygen deprived regions commonly found within tumors. Once there, the bacterial population increased by roughly 3,000 fold within 24 hours after treatment, directly damaging cancer cells.

Second, the bacterium stimulates the immune system. Its presence attracted T cells, B cells, and neutrophils into tumors. These immune cells then released inflammatory signaling molecules, including TNF- and IFN-, which strengthened the immune response and promoted cancer cell death.

One of the most striking findings was that E. americana accumulated almost exclusively inside tumors and did not colonize healthy organs.

They found that the bacteria were rapidly cleared from the bloodstream, with a half life of approximately 1.2 hours, and became undetectable within 24 hours. No bacterial colonization was detected in healthy organs, including the liver, spleen, lungs, kidneys, or heart.

The treatment caused only mild, temporary inflammation that returned to normal within 72 hours. During a 60 day observation period, the researchers found no evidence of chronic toxicity.

Comment Re:To be clear... (Score 2) 66

Because you usually need to update your MB code from the UEFI interface, you might think that is necessary to access UEFI code.
It is not.

Didn't we already see a significant vulnerability related to this within the past 12 months?

Also, it's not just Windows. Just a couple months ago I updated the firmware on a bunch of Dell boxes using fwupdmgr (on AlmaLinux 9). It's very convenient, but I (mostly) wish it wasn't actually possible... but, since it is, might as well take advantage of it.

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"The algorithm to do that is extremely nasty. You might want to mug someone with it." -- M. Devine, Computer Science 340

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