We're learning that hallucinogens can indeed do wonders for depression and can even result in some degree of brain repair, but they are also capable of worsening depression, causing further brain damage, and even creating whole new conditions the patient hadn't previously suffered with.
This has been under discussion for well over two decades, in both the US and UK, and, frankly, I'm horrified that there hasn't been much, if any, meaningful research in many of the substances, with the result that the horror stories rival the success stories in magnitude. We could have avoided ALL of that simply by finding out who benefitted (is there a specific set of conditions? a genetic contribution to outcome?) and who worsened. It was gross incompetence by the governments of both countries and the corresponding health research grant bodies, who damn well AUGHT to have done the legwork, because it was perfectly obvious to everyone that if nobody got told anything practical, people would start experimenting on their own. A far worse outcome, because now we've no idea of why the difference in results, nor what can be used to repair damage where damage is repairable.
Ignorance is useless. The craving of it is, in all honesty, extremely irritating.
By now, after two decades of calls, we should know precisely what genetic and experiential outcomes make which substance applicable and what the correct and safe therapeutic dosage should be. We don't. We don't know anything. Oh, sure, we know it helps some people, but we can't predict who, why, when, or how to repeat those results without messing things up. We've had two flipping decades to learn that. We didn't.
I am, as you might have figured out, not happy, although that might not be obvious to all.
I am not going to say substance X is good/bad/ugly, because (a) no substance works that way, and (b) nobody did the proper research to find out.
(Yes, there has been a little bit, here and there, but nothing I'd consider systematic - it's very piecemeal and not much of it has been replicated. But it's not enough to have any confidence in reliable results.)