Microkernel architectures still always involve doing a full context switch when moving between processes. All the registers need to be reloaded, importantly including the entire page table. The page table flush is particularly painful.

Hochul said this? Yeah, sheâ(TM)s just grandstanding because she is desperate to keep her position. Sheâ(TM)s wise than Cuomo was, and keeps somehow fumbling the ball in every way possible. This woman is a disaster for the state of New York.

She squandered $300 million by stealing it from Department of children and family services to fund a pork project for her husband that no one asked for, a stadium in Buffalo that is useless most of the year.

This woman is politically inept, and is so blissfully unaware of the gravitas of this moment in history it is laughable. There is no way she will give anything to upstate New York. She is continued to defund and starve upstate New York of desperately needed infrastructure money, which is one of the worst things she could possibly do.

besides, NYPA would take 5-10 years to finalize these plans. At best we are talking15-20 years to get this project done.

Shame on you Slashdot, you are posting stupid political grandstanding instead of interesting articles.

I agree that this therapy is not without significant risks, so it's not to be taken lightly.

That said, the long-term health outcomes of T1DM are also significant. So the way I see this development is that it is one more step on the path toward finding a durable, safe, and effective cure. And if approved, it may offer some patients another choice, one that of course should involve an informed discussion with competent healthcare providers.

It's important to keep in mind that healthcare is not a "one size fits all" thing. Two patients that have the same condition can respond very differently to the same therapy. Before the discovery of insulin, diabetics literally just...died. So on the path to understanding this relationship between the individual patient and the selected therapy, medical science can only offer a range of treatment options. At one time, humans believed in bloodletting, lobotomies, and arsenic to treat various illnesses. We built leper colonies. And in some places in the world, menstruation is still considered "dirty." We have made many advances, but there are still many more to be discovered.

They keep doing them because they sell REALLY well in China, dwarfing the American box office.
What modern Hollywood is telling you is that China already runs things. When China stops being interested in superhero movies, then we'll see a change here.

I'd rather use a slower browser that honors the user's choice of extensions--in particular those that block malicious content and privacy-violating advertising trackers--than an ostensibly faster browser that is created by a company whose entire business model is to gather as much tracking data about you in order to sell it to advertisers.

There are alternatives to both Firefox and Chrome. But choosing to use Chrome because Firefox isn't perfect is either the height of idiocy, or being paid to promote Google products.

Every accusation is a confession. Golf clap for starting down the road to self acceptance.

Disagree.

Maslow's lacks cultural broadness and his methods were highly suspect.

https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fsimplyputpsych.co.uk%2Fp....

And THIS is the kind of post I hoped would be at the top of the mod heap.
Very thoughtful! Thank you.

I worked like to add two things:

One, this study seems as if it would look at what people THINK they want.

Two, it is what they want right now. As we move toward a world where more and more people have less and less, I argue this is what people want right now, rather than what brings contentment long term.

Finally, as a Buddhist, I argue people REALLY REALLY have no idea that what they are looking for is a calm contentment. That comes from an outlook/conditioning of having enough. Sex and fun are just hedonism, which make us want more. Then we suffer to try and obtain more (looking at you, Elmo...) but it's neeeeever quite enough.

The real issue is infrastructure. people who live in apartments canâ(TM)t charge their cars and there arenâ(TM)t enough charging stations at work for people to plug in there.

people donâ(TM)t have time to wait 30 minutes or an hour to charge their car. They just plain donâ(TM)t. unless there was charging at grocery stores or something, which there also isnâ(TM)t!

Add to this the fact that about half the United States lives in a place that has really cold weather in winter and loses mileage. Battery heaters be damned.

The people who try and hand wave away these issues in the comments are living in an ivory tower. They have no idea what the average American is struggling through. there is no transition to EVS without enormous infrastructure investment in America, and since that obviously wonâ(TM)t be happening anytime in the next four years, I guarantee you that these EV investments from car companies are going to be a bust.

Jordan's original idea was a trilogy.
in the third book Rand is supposed to get balefire and then that's it. He wins.

he was successful with the books so he drew the whole thing out the same way that GRRM is doing.

Any time you see great wealth there is a great crime behind it.

I do, and there's nothing you can do about it because this is the internet so nyah nyah nyah!

Came for this, left satisfied. Would read again.

Birth defects due to thalidomide approval outside of the US were extensive, and you conveniently ignore this. That wasn't some media psyop: 20000 affected embryos for a drug marketed to prevent morning sickness is not something to trivialize, and the fact that it was not approved in the US meant that many American families were spared this horror.

It's ironic that you mention Type I and Type II errors, yet conclude--without any apparent consideration of such errors as they apply to the establishment of efficacy and safety--that somehow "Montana has the right idea." How would they have the right idea if anyone can choose to receive unapproved drugs before any data collection and statistical analysis is performed? That to me suggests you don't have the faintest clue about what a Type I error means.

This is a horrible plan on so many levels.

An investigational treatment that has passed Phase I only has the most basic pharmacokinetic and safety data gathered. There's virtually no efficacy data. The layman who thinks that patients with serious and unmet medical needs should have access to such treatments before efficacy is established, believes so because "what other options do they have?" Their logic is that they should be "free" to try anything.

But the primary reason why this logic is flawed is because a very high proportion of treatments at this stage of clinical development are inadequate--they are either ineffective or unsafe, or both. The second reason--one that never crosses the layman's mind--is that providing such early access would cripple trial enrollment. If even one state passes legislation to circumvent regulatory oversight, then patients will simply demand access through that state, rather than enroll in a trial and deal with the burden of following the trial protocol and procedures. And this will absolutely cause statistical and ethical problems with analyzing efficacy and safety in a trial context. The result will be either a serious delay in securing marketing approval for therapies that do succeed, or even worse, pharmaceutical companies will simply sidestep the regulatory process entirely and just start make marketing claims for untested compounds. After all, why bother spending hundreds of millions of dollars on a development program to secure approval if one state lets people try whatever they want?

One more comment: drug companies do have a pathway for patients in dire need. It's called "compassionate use" or "expanded access." So it's not like there's a brick wall preventing patients from accessing investigational therapies when they do not meet the inclusion criteria for a trial. But opening the floodgates is going to hurt way more people than it might help.