Please do let us in on the joke and share your explanation of what you find so funny about this phrase.

...Modern ejector seats cause spinal injuries from which full recovery is "unusual". Smashing the spines of pilots might not be the most effective way to boost morale.

$22,000 per hour. The F35 will be nearer $42,000 per hour. These are under-estimates, as they do not include price hikes, crashes that close businesses, crashing into businesses, crashing into heavily-populated sports centres, etc.

It means Iran has severely limited the capacity of the Strait of Hormuz. It's a hostage situation. No one is winning, but the objective isn't to win in the sense of completely closing the Strait, the objective is to create a sufficiently long period of pain that eventually the US and its allies walk away. Christ almighty, force multiplication is hardly a new concept.

There are plenty of places in North America without coverage because there's so little to cover. The Los Vegas metropolitan area has about three million people. So yes, that would be a place with cell phone coverage. By the same token, coverage in states like Montana, particularly in mountainous areas is spotty because, well, there's not a lot of people.

Are you fucking stupid? Names actually are useful, which is why we propers nouns at all.

Jesus fuck the supporters of Trump really are a pack of morally compromised halfwits.

I suspect you were just asked to be nice, and through a combination of spectrum OCD and insufficient cognitive therapy, you decided somehow you were being asked to do something wrong.

So you helped elect an ignorant sociopath. Congrats on that. Maybe you should have attended more of those cognitive therapy sessions.

Currently, there are no known functional cures for AD. There exist a number of treatments (monoclonal antibodies) for which there is supporting evidence for slowing cognitive decline and delaying the progression of functional disability, but the effect size is generally modest. To be fair, some people seem to be stronger responders than others; however, these amyloid-targeting treatments also have a risk of ARIA (amyloid-related imaging abnormalities), which are associated with microvascular hemorrhages (bleeding of the small blood vessels in the brain).

A subgroup of the general population is predisposed to AD because of a genetic mutation they carry (ApoE4). Each of us carries two copies of this gene, and we know that people who have one mutant copy (heterozygous) have a modestly increased risk of developing AD, and those with two mutant copies (homozygous) have a significantly higher risk. Not only is the lifetime risk increased, the typical age at onset is decades earlier; homozygotes may begin showing MCI (mild cognitive impairment) as early as in their 40s, and we call this "early-onset AD."

So, to answer your question, you are correct: there isn't really anything someone can do to stop or reverse the condition, but with early detection and treatment, they might be able to improve their quality of life and reduce the burden on caregivers and long-term financial cost of care. How such a person copes with a diagnosis is a psychological question. Some will spiral into depression and despair. Others might plan for the future in ways they might not have done otherwise, and find focus and purpose during the time they have. And it is for this latter group that the availability of such a test might be particularly helpful.

That said, having a validated and (relatively) noninvasive biomarker for AD pathology is a huge game-changer for AD research and drug development. One of the biggest challenges for targeting AD is accurately identifying the patient population. In the past, it was not always clear whether trial participants--many of whom were elderly (i.e. 75+)--actually had AD, or some other dementia, since the gold standard was to perform an autopsy. Because of this, clinical trials often suffered from a lack of statistical power due to a proportion of participants not actually having the disease that drug was intended to treat.

Since then, we devised various imaging modalities (e.g., PET) to use in conjunction with investigator assessment to improve population quality, but the more measures we have, the better the trial data gets, and the better researchers can identify targets for drug candidates. But we are still a long way off from figuring out how to prevent and/or reverse AD. One reason is that we believe that by the time patients exhibit symptoms of cognitive impairment, it's already too late--there is already extensive damage. So if there is a biomarker that can reliably detect subclinical AD pathology, this also has positive implications for designing clinical trials that aim to prevent AD disease in susceptible people, much like a vaccine for infectious disease or cancer.

It's a big dream, like being able to prevent or cure all forms of cancer. But I would like to imagine it is possible. These diseases take such a tremendous toll--on patients, on their caregivers, on the healthcare system, on society--and I hope there will come a day when they can be prevented as easily as going to your local pharmacy and getting a shot.

Jesus Fucking Christ. It's 2026, Trump has been putting his boot on the necks of major networks and studios for a year and a half now. I realize you probably fell into a coma in 2016, but ten years later, the free press, regardless of what you think of it, or fair you imagine it is, is under direct assault. Fuck off with the "MSM" bullshit and grow the fuck up.

Whether we like it or not, whether we use Windows or not, Microsoft is going to insist on adding the tax whether the PC comes shipped with Windows or not. This is illegal bundling, Microsoft has essentially ignored prior rulings, and it's pretty much a certainty the courts will be fine with this.

"How did you get hired?"
"I was top at Fortnite. You?"
"Combat flight sims."

"Damn, two Boeings just crashed over an oil refinery on city limits and took out half the city."
"Did you remember to save your position beforehand?"
"Yeah."
"The reload and continue from there. No-one will notice."

I love computer games. I have XPlane 12 and many scenery packs. I rank well on Elite:Dangerous. From the sounds of it, the FAA would see me as over-qualified. In reality? There's no way in hell I'd be taking those kinds of risks with real lives. There's a huge difference between having good reflexes and a good eye, versus having the complex 4D spacetime relationship mental models needed for robust air traffic control.

We generally don't let the general public have access to enriched uranium, high explosives, or chemical or biological agents. These are also just "technologies." Anyone sufficiently intelligent CAN gain access to hazardous materials. But we don't allow it because society has recognized that these things are too dangerous to not tightly regulate. Unauthorized possession is itself considered a crime, and this is because of the risk level.

AI agents might not reach this level, but this example serves to illustrate that your arguement--that "outlawing technology is not the answer"--requires more nuance. Many gun owners are fond of saying that "guns don't kill people, people kill people." That is also a specious argument. The gun makes it much, much easier to do it, and to do it in a way that is faster, more deadly, and more difficult to trace.

And the way these AI systems are designed is similar: whereas before, a competent hacker could go in and manually find vulnerabilities, now the process is automated and not even explicitly asked for. That's the crux of the matter: the more capability we train this technology to have, the more dangerous using it will become--just like a revolver pistol versus a chain gun.

The solution is not just technological or even legal. It's a societal one. We need to first acknowledge that agentic AI technology is intrinsically burdened with very serious risks, by understanding what it is actually and potentially capable of doing. We are at a phase of LLM development where there is a great deal of power exhibited by and granted to these tools but very little regulation due to the lack of such understanding. It might evolve to a point where computing systems have built more robust protections against abuse (whether intentional or not). It might evolve to a point where laws will be passed restricting certain uses. But to your point, the genie is already out of the bottle, and unlike, say, the relatively successful proliferation of age-verification laws and censorship of legal adult material worldwide under the pretense of "protecting children," the real reason why there hasn't been a massive concerted effort to prevent AI abuse is because the people who have the power to restrict it are the same ones who are making billions of dollars off promoting its use.

How difficult is it for an operating system update to detect whether or not a service is installed, and if not, then not install it unless it is explicitly requested?

I find it strange that this simple design philosophy is ignored. When a user installs or updates software, they should be presented with a dialog box with a list of components that can be checked/unchecked for installation, with any dependencies reflected as appropriate. The whole paradigm of "automatic" and "background" updates is absolutely bizarre to me. I never want the OS to decide if or when to update itself. I never want it to decide by default to install and enable a new service without giving me the option to choose. Microsoft seems to violate this principle with alarming regularity.

The fact that OneDrive at one point its its development caused massive data loss for users who found it had exfiltrated their locally stored files means that at no point in its future development can it be trusted. The risk is too high to not check whether it has deleted the local copy, relative to the inconvenience of performing the check.

You see, Linus has embraced transhumanism and is testing out the new kernel as a supplementary brain function, using MOSIX to offload all of the irritable comment generation at yet more nonsense on the mailing list to an Elizabot that he has written specifically to do this. This saves his actual brain for real work.

AI is not currently capable of performing any meaningful conceptual abstraction, it is only capable of very basic mechanical abstraction. Abstraction is itself multi-dimensional. Nor is there any indication that AI could ever perform multi-dimensional abstraction or multi-dimensional decomposition. Precious few humans are capable of it either, but some can.

No, AI would need humans because the best system is not a pure system but a hybrid system, and that means transhumanism with AI operating as an additional brain function rather than as a replacement for a brain.