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Comment Crostini was years late (Score 1) 29

The practical problem with Chromebooks at the time was that for several years, between the debut of Chromebooks in 2011 and widespread support for Crostini (a GNU/Linux virtual machine) in 2019, a Chromebook couldn't do anything other than browse the web without threatening to wipe all your data (because "OS verification is OFF") every time you turned it on. That isn't very conducive to offline use while (say) riding a bus. I had been using my netbook for lightweight hobby programming projects.

Comment Re:Great news (Score 2) 68

Sorry I can't point you at a reference, but thing is that the mitochondrial environment is a really bad place for DNA to live, so over evolutionary time some of the bacterial DNA moved into the cell nucleus. Mitochondria is now an "obligate parasite", though parasite is *really* the wrong term. (I can't think of the term for obligate symbiote.)

OTOH, I'm talking about the function rather then the physical pieces. This is probably similar how some of our DNA "moved into" the plants that we eat, so now we are dependent on them for vitamin C. But the result is that much of the DNA controlling the mitochondria now resides in the cell nucleus.

Comment The disadvantage of a bigger laptop (Score 2) 29

and small screen laptops were on the wane, as larger, higher resolution displays were coming out.

The disadvantage of a bigger laptop is that a bigger laptop is less convenient to use in a cramped space, such as on a bus commute to and from your day job. It's also less convenient to pack in a cramped space, such as your tiny personal locker at your day job. A 10.1" laptop fit in (say) a locker in the back of a Walmart Supercenter, and a 11.6" laptop did not. That's part of why I was so disappointed that manufacturers suddenly discontinued 10.1" laptops at the end of 2012. I remember recommending that people affected by this discontinuation buy a cellular iPad, a Bluetooth keyboard case, a VPS, and an expensive data plan, and use the iPad to remote desktop to the VPS. I rejected that workaround as cost prohibitive at the time.

Comment Re:GMO Humans (Score 1) 68

This isn't gene line surgery. It's inheritable only along the female line. (But, yeah, mistakes WILL happen. Even normal mitochondria have a high mutation rate. And those with problems will be disadvantaged, and probably have no grandchildren. And if they do, only the granddaughters will spread the mutation.)

Comment Re:GMO Humans (Score 1) 68

A point, but given the mutation rate of mitochondria, not a good one. More to the point, if it doesn't fix the problem, or creates a worse problem, the kids probably won't reproduce.

Also, since mitochondria are inherited almost only along the maternal line, it won't spread widely. It will be confined to the descendants in the female line of one family. (Sons may carry it, but won't spread it.)

Comment Re:Great news (Score 1) 68

Mitochondria from the father would be equally experimental. Mitochondria are almost never inherited from the father.

But, yeah, it's experimental. Some mitochondria don't play well with some nuclear DNA combinations. (Part of the mitochondrial DNA is stored in the cell nucleus.) But it won't create a "new genetic disease" because those things already happen once in awhile. It's just that it might not fix the problem. Presumably they check that before they do the implantation though.

Comment Re:Congrats to Linux Devs and Distros! (Score 1) 147

Does a Windows game run 100% in WINE?

YES! Many happy users of Proton on Steam Deck will answer in the affirmative for many games. This is what Valve's 30 percent cut of Steam sales pays for.

If *Nix was just a simple drop-in replacement without all the config issues that require an hour of reading to fix

As if Windows 11 doesn't have its own host of "config issues that require an hour of reading to fix."

Comment Re:Charging a nominal fee is the way to go (Score 1) 54

No. It needs to be high enough that the submitter limits the number of submissions. I expect that $1 would suffice, but that's a guess.

OTOH, I'm reluctant to pay money over the internet, so I am usually only willing to do so if I have a previous financial-over-the-internet transaction history. So it might limit the valid bug reports/suggested fixes.

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