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Comment Transitioning to touch typing (Score 1) 188

Before I learned to touch type, I had managed to get pretty fast (I would estimate maybe 20-40 wpm) using a primitive hunt and peck technique. I more or less knew where they keys were, so I could use both hands and multiple fingers to type, but I needed to switch from looking at the screen to looking at the keyboard in order to not make mistakes.

After learning to touch type (on an electric typewriter - not a word processor), I probably tripled my speed, but the biggest advantage was being able to stay in context by looking at the screen instead of switching between the keyboard and the screen, and being able to fix mistakes while I was typing instead of having to go back and fix them after looking back up at the screen.

Of course, this was all pre mouse/gui, when memorizing and using keyboard shortcuts was not just a way of speeding up your workflow, but a requirement for basic functionality unless you wanted to continuously have the reference card taped to your desk.

In today's world, with continuous autospell correction, word and sentence completion, and even automated message reply suggestions... you can argue that actually typing as a form of communication is starting to become as antiquated as handwriting. The human is now more of a middle manager to all the machine tools, trying to put their individual stamp on the work of their electronic underlings (including LLM output).

Up until now, communication between humans was still a necessary and valuable skill. What happens when it is just bots writing memos to be read and summarized by other bots? I've already run into problems with people just refusing to read things and wanting meetings instead. Meetings don't scale, but apparently reading is just too hard... In that context, does it still make sense to put your skill points into writing things when people refuse to consume that output?

Comment Re: fuck off muhammad (Score 1) 52

https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fwww.perplexity.ai%2Fsear...

research anticarcinogenic properties of cow urine

## Anticarcinogenic Properties of Cow Urine

**Summary of Research Findings**

- Multiple studies indicate that cow urine, especially from breeds like Red Sindhi, exhibits notable anticancer properties in animal models. These effects include:
    - Inducing apoptosis (programmed cell death) in cancer cells
    - Inhibiting tumor growth
    - Reducing tumor size and incidence
    - Enhancing immune function and antioxidant activity, which help combat cancer progression[1][4].

- Cow urine distillate (CUD) has been shown to act as a bioenhancer, increasing the effectiveness of anticancer drugs such as paclitaxel (Taxol) against breast cancer cells in lab studies[3][5]. US patents have been granted for its role as a bioenhancer and for its anticancer effects[3][4][5].

- The anticancer mechanisms are thought to involve:
    - Modulation of cell cycle regulatory proteins (such as p53)
    - Suppression of anti-apoptotic pathways (e.g., PI3K/Akt, NF-kB, Bcl-2)
    - High antioxidant activity, reducing oxidative stress that contributes to cancer development[1][4].

**Clinical Evidence and Limitations**

- Some case reports and observational data suggest cancer patients using cow urine preparations (like Kamdhenu Ark) experienced symptom relief or recovery, but these are not controlled clinical trials[4].
- Most evidence is preclinical (animal studies, cell cultures); rigorous human clinical trials are lacking[1][4].
- The beneficial effects are attributed to phenolic compounds and other bioactive molecules found in cow urine[4].

**Conclusion**

Cow urine demonstrates promising anticarcinogenic properties in preclinical studies, including tumor inhibition, immune modulation, and enhancement of standard anticancer drugs. However, robust clinical trials in humans are needed to confirm its efficacy and safety for cancer therapy[1][3][4].

Citations:
[1] Exploring the pharmacological potential of Red Sindhi Cow urine https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fwww.ijmmtd.org%2Fhtml-ar...
[2] Chemotherapeutic potential of cow urine: A review - PMC https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Fa...
[3] Cow urine distillate as bioenhancer - PMC https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Fa...
[4] [PDF] Anticancer activity of cow urine distillate, an update https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fpdf.ipinnovative.com%2Fp...
[5] Study of CIMAP related to Use of cow urine for curing Cancer - PIB https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fwww.pib.gov.in%2Fnewsite...
[6] In Silico and In Vitro Studies of Antibacterial Activity of Cow Urine ... https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fonlinelibrary.wiley.co...
[7] Peptide profiling in cow urine reveals molecular signature of ... https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fwww.nature.com%2Farticle...
[8] Research papers proved cow urine has antifungal properties: IIT-M ... https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fwww.deccanherald.com%2Fi...

Comment Re: Would anyone have noticed? (Score 0) 61

I own a tiny indie studio in Chicagoland and my peers own the some of the huge studios in Chicagoland.

Cinespace is dead right now. It has ONE show active. The other studios are so dead that they're secretly hosting bar mitzvahs and pickleball tournaments for $1500 a day just to pay property taxes.

My studio is surprisingly busy but I'm cheap and cater to non-union folks with otherwise full time jobs.

Comment Re:Kurzweils Singularity. (Score 1) 157

Really not sure where your anger is coming from? You're the one who claimed that the Spanish came over "in sailing ships the size of small Inca cities", I'm just pointing out the historical inaccuracy of this. Machu Picchu was just an estate, as you note not even able to feed itself except as part of the overall Incan economy, and that estate was already larger than the crew sizes of the larger Spanish vessels.

Not sure what your point is about carracks? Those were the predecessors to and usually smaller still than galleons -- the Santa Maria was classed as a carrack, and that had a crew complement of only 40. The largest carrack built as of 1502 was the Portuguese Frol de la Mar with a complement of 500, but it looks like most carracks were substantially smaller. Bearing in mind the context we were talking about of when European diseases were brought over, that historical timing makes galleons irrelevant anyway, since they don't really become a thing until the late 1500s. I used that ship size as a quick-and-easy estimator, as I had tried to make clear in the wording of my earlier post.

About settlement size, "city" in general parlance, even in modern contexts, refers to the larger size of community. If you intended something smaller, even smaller than the 40-person crew of the carrack Santa Maria, then yes, you should have used a different word. I would never consider a community of a few tens of people to be a "city", more of a "hamlet"; a few hundreds on up I might consider a "village", a "town" would be up to a few thousands, whereas "city" even in antiquity calls to mind populations of several thousands. The ancient city of Uruk, for instance, regarded by some as the first known real city, had a population of some 40K.

About “As for "you're not sure you can agree"? Are you serious?” — that's an example of being politely indirect.

Comment Re:Kurzweils Singularity. (Score 1) 157

The Inca, possibly the most advanced civilization on the planet at the time

What an idiotic statement.

were brought down by the diseases bred in the filth of medieval Europe

Brought over by motherfuckers in sailing ships the size of small Inca cities using astronavigation.

FYI, Carlin was talking about you.

Spanish galleons were bigger than the earlier conquistador exploratory ships. Apparently they had crews of up to around 400 people on a single ship. Let's use that higher number, for sake of argument. That's close enough to the entire size of Cortés's expedition force when he set out to conquer the Aztecs, about 500 men, albeit spread across 11 ships.

The Incan outpost of Machu Picchu was only ever a small settlement, in its early days basically a royal estate. Even then the town had about 750 people, larger than the crew of a galleon. The proper city of Chan Chan in the neighboring Chimor empire had a population estimated at some 40-60K, yet again a wee bit more than could fit on a galleon. The Chimor empire was conquered by the Incas around 1470. By comparison, the population of London in 1377 was estimated at some 40K, growing to an estimated 50K by 1500.

Just in terms of the numbers of people, your math ain't mathing.

If we pay attention to recent developments in lidar and surveys of now-overgrown areas in Amazonia, archaeologists are finding more and more long-forgotten settlements, showing that what we now think of as remote and largely unpopulated jungle regions were actually home to extensive human settlements in the past.

I'm not sure I can agree with cusco's claim of Incan advancement, but their death-toll estimate might not be far off. It is increasingly clear from mounting archaeological evidence that the advent of European diseases in the Americas caused a rapid and enormous depopulation.

Comment Re:Kurzweils Singularity. (Score 5, Informative) 157

Life is WAY better after the industrial revolution than it was before it.

People have this fantasy image of what life used to be like, thinking of picturesque farms, craftsmen tinkering in workshops, clean air, etc. The middle ages were filth, you worked backbreaking labour long hours of the day, commonly in highly risky environments, even the simplest necessities cost a large portion of your salary, you lived in a hovel, and you died of preventable diseases at an average age of ~35 (a number admittedly dragged down by the fact that 1/4th of children didn't even survive a single year).

If it takes people of similar social status as you weeks of labour to produce the fibre for a set of clothes, spin it into yarn, dye it, weave it, and sew it, then guess what? It requires that plus taxes and profit weeks of your labour to be able to afford that set of clothes (and you better believe the upper classes were squeezing every ounce of profit from the lower class they could back then). Decreasing the amount of human labour needed to produce things is an immensely good thing. Furthermore, where did that freed up labour go? Into science, into medicine, into the arts, etc etc. Further improving people's quality of life.

And if your response is "But greater production is more polluting!" - I'm sorry, do you have any understanding of how *miserably* polluted cities in the middle ages were? Where coal smoke poured out with no pollution controls, sewage ran straight into rivers that people collected water from and bathed in, where people extensively used things like arsenic and mercury and lead and asbestos, etc etc? The freed-up labour brought about by the industrial revolution allowed us to *learn* and to *fix problems*.

Comment Re:No it isn't (Score 2) 157

Which of those things hit 800 million users in 17 months?
Which of those things hit such high annual recurring revenue rates so fast?
Which of those saw the cost of using the tech decline by 99% over two years?

Heck, most of them aren't even new technologies, just new products, often just the latest version of older, already-commonly-used products.

And re. that last one: it must be stressed that for the "cost of using the tech" to decline 99% over two years per million tokens, you're also talking about a similar order of reduction of power consumption per million tokens, since your two main costs are hardware and electricity.

Comment Re:Dig Baby Dig (Score 4, Informative) 157

You're looking at three months of very noisy data and drawing some pretty dramatic conclusions from said minimal data.

Winter demand is heavily dependent on weather. You're mainly seeing the impacts of weather on demand.

https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2F2024%25E2%2580%259325_North_American_winter

"The 2024–25 North American winter was considerably colder then the previous winter season, and much more wintry across the North American continent, signified by several rounds of bitterly cold temperatures occurring."

Comment Re: Maybe we should all pool our severance package (Score 1) 10

https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fm.slashdot.org%2Fsubmiss...
Perplexity predicts layoffs due to AI: timeline+country

https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fwww.perplexity.ai%2Fsear...

https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fm.slashdot.org%2Fsubmiss...

please click ðY' at link above
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