Wine should be able to take care of this. Once the processor gap has been filled in, wine should be able to run most windows apps without Windows and without restarting. Work had already been done up to this point on porting Wine to PPC. They got it working, but you have to re-compile your code for x86. Their next step was to interface it with QEmu to allow emmulation as well. Looks like they don't have to do that now.