I was on a proton pump inhibitor for some time, and it helped amazingly. And then in came out that they are linked to greater rates of osteoporosis, already much more likely in women. So instead I ended up with taking a Zantac 300 (twice the highest OTC, I believe, at least at the time) every night before bed, before I finally found a permanent solution.
I got a divorce, and suddenly my stomach acid problems went away...
Oh, and even with mainly taking OTC short term acid medications (read: eating Tums like candy), my father ended up with some vitamin K issues, I think it was? He ended up with shots to bring things up to normal. I think it was Vitamin K, but whichever vitamin, it was one that is mainly gained in humans from eating meat, and he apparently had brought his acid so low that he wasn't breaking down meat enough to have adequate levels. (Note: this information is obviously second hand, so there might be some Telephone effects.)