Rational used to have some real problems if word munged the docs at all; I've seen the database get out of sync with the word files many times. After quite a bit of rework getting stuff back in sync or reverting to backups, we gave up. We were far enough into the process that I just rolled my own database. The cost of a week or two's work was significantly less than something like Doors and gave us all the basics we needed for managing requirements and bugs all the way through the program's lifecycle. Last I heard it was still in active use over several projects.

Sometimes rolling your own isn't a complete nightmare, especially if someone on the team really understands the needs and processes (which is the *point* of CMMI).