Comment Re:Lupus and Scleroderma in the same family (Score 1) 46
This is some info regarding scleroderma that I have shared with my friend with scleroderma over the years. I suspect some relationship to Lupus. Maybe this can help someone.
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Take a look at this article on autoimmune diseases.
https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fwww.lifeextension.com%2F...
It suggests vitamin D and Omega-3s:
_The daily supplemental dose was 2,000 IU of vitamin D3 and 1,000 mg of omega-3 fatty acids._
https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fjournals.plos.org%2Fplos...
Here the core paper behind this article. They induced and cured an MS- like condition in animals by deactivating something called an 'aryl hydrocarbon receptor' in T cells. The receptor makes T cells overactive. This is what triggers sclerosis
Interestingly
- the receptor is sensitive to hydrocarbons (petrol, benzene, dry cleaning, cleaning chemicals)
- the receptor is sensitive to blue and UV light (getting a sunburn or tan)
So this should help:
- removing sources of volatile hydrocarbons
- avoiding blue/UV light and substituting with red light therapy (which energises mitochondria)
This paper seems promising.
https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fp...
I believe skin sclerosis occurs in scleroderma, correct? This paper basically says UV light that's normally used to treat skin sclerosis may be too damaging to certain tissue components. Instead, Red Light therapy is a promising treatment for skin sclerosis as it does not have these side effects. The paper recommends investigating its use in treatment.
*Excerpts:*
_Ultraviolet (UV) phototherapy is a non-invasive modality that has been used to treat several diseases associated with skin fibrosis including morphea, systemic sclerosis, chronic graft versus host disease, and nephrogenic systemic fibrosis [5–7]. However, UV phototherapy causes thymidine dimer DNA damage that is associated with an increased incidence of skin cancers and premature photoaging [8–10]. In addition to these safety concerns, UV phototherapy units are often prohibitively expensive for home use and require fluorescent or incandescent bulbs that limit portability. Therefore, UV phototherapy requires frequent office visits that patients often find burdensome [11, 12]. In contrast, light-emitting diode-generated red light (LED-RL) phototherapy is a safe, non-invasive, inexpensive, and portable treatment that may be combined with existing treatment modalities. Furthermore, the visible red light spectrum has superior depth of penetration, when compared to UV light, that allows it to penetrate the epidermis and reach the dermis to affect fibroblast function [13]. LED-RL is not known to cause thymidine dimer DNA damage or to be associated with an increased incidence of skin cancer [14]. However, the underlying biochemical mechanisms and clinical effects of visible light photobiomodulation of skin fibrosis are not well characterized._
*_Conclusions_*
_Visible light phototherapy is an emerging therapeutic modality for treatment of skin fibrosis. There is a growing body of evidence demonstrating that visible red light is capable of modulating key cellular characteristic associated with skin fibrosis. We believe that further laboratory research may elucidate the underlying mechanisms and effects involved in visible light photobiomodulation. LED-based devices are the optimal devices for red visible light phototherapy. There is a current lack of clinical trials investigating the efficacy of LED-RL to treat skin fibrosis. Randomized clinical trials are needed to demonstrate visible red light’s clinical efficacy on different types of skin fibrosis._
"The technique, called transcutaneous auricular vagus nerve stimulation (tVNS), which involves electrical stimulation to the vagus nerve through the skin on the outer ear and can be done at home, also resulted in lower levels of IL-6, an inflammatory molecule with a known role in SSc"
https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fsclerodermanews.com%2Fne...
https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fwholefamilyproducts.co...
There is a Japanese supplement called serrapeptase. It dissolves unwanted protein and is used by silkworms to free themselves from their cocoon.
It is useful for scleroderma.
https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fwww.inspire.com%2Fgroups...
This thing called natto, a Japanese fermented soy food, may be good for you. See this enzyme extracted from it is "fibrolytic" - dissolves clots and scars.
https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fchatgpt.com%2Fshare%2F67a7...
can you have a read of the attached AI session and then ask your specialist about rhubarb extract containing rhein?
This is a very interesting supplement. small amounts reboot mitochondria, and increase energy
https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fyoutu.be%2FqdN3q8MFJIM%3Fs...
https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fyoutu.be%2FMBXBpm1Y5J0%3Fs...
This seems useful: a video on diet in managing scleroderma. At 15:57 he makes a very interesting point that 50% of calories must come from Omega fats. He says carnivore diet helps by eliminating carbs that feed harmful gut bacteria. But he recommends the carnivore diet only during scleroderma flares. In the main, he recommends a customised 'phyto-diet' based on plant foods
https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fyoutu.be%2FvmBHj-5SUWY%3Fs...
This video lists different useful natural supplements for Sjogren's syndrome - a somewhat related autoimmune disorder that overlaps with scleroderma 20% of the time. The recommendations here each target specific different pathologies and root causes (the CMV and EBV viruses). I feel these will be useful for you. He talks about supplements including wormwood and cordyceps mushrooms