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Comment Re:Pills Won't Stop Your Sin (Score 1) 181

Let's add some numbers to that math:

The overlapping physiological changes that occur with weight loss help explain the near-ubiquitous weight loss time course: early rapid weight loss that stalls after several months, followed by progressive weight regain32. Different interventions result in varying degrees of weight loss and regain, but the overall time courses are similar. As people progressively lose more and more weight, they fight an increasing battle against the biological responses that oppose further weight loss.

Appetite changes likely play a more important role than slowing metabolism in explaining the weight loss plateau since the feedback circuit controlling long-term calorie intake has greater overall strength than the feedback circuit controlling calorie expenditure. Specifically, it has been estimated that for each kilogram of lost weight, calorie expenditure decreases by about 20–30 kcal/d whereas appetite increases by about 100 kcal/d above the baseline level prior to weight loss31. Despite these predictable physiologic phenomena, the typical response of the patient is to blame themselves as lazy or lacking in willpower, sentiments that are often reinforced by healthcare providers, as in the example of Robert, above.

https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fpmc.ncbi.nlm.nih.gov%2Fa...

Comment Re:Sounds cheap and easy (Score 2) 85

by SNRatio (#65383917) Attached to: The Most Promising Ways to Destroy 'Forever Chemicals'
Except someone would have to pay for that. Meanwhile, the Federal government just eliminated the laws requiring municipalities to monitor some of the forever chemicals and delayed implementation for six years for others.

So municipalities won't be measuring for this, won't be forced to fix it if they find something, and won't be getting any money federal money to fix it if they want to.

Comment Clinical trial results (Score 1) 48

by SNRatio (#65204113) Attached to: Anti-Aging Pill for Dogs Clears Key FDA Hurdle
The same way you know about the safety and efficacy of other drugs:

https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Floyal.com%2Fposts%2Four-lo...

If they don't register and make public the details of the trial well before the results are announced, if they don't replicate it in a second trial, if their study size, duration, or retroactively chosen endpoints are cheesy, well, so much for that. The $100M question though is will they find a way to sell it off label to humans?

Comment Re:Federal conviction upheld on appeal, so ... (Score 1) 101

by SNRatio (#65195603) Attached to: Theranos Founder Elizabeth Holmes' Fraud Convictions Upheld

Depends on the investors. If she conned George Soros: pardon. But instead she conned:

- Larry Ellison, who participated in Trump's 2020 attempted election theft

- Fortress Group, which loaned money to Trump, forgave the loans, and received favors in return

- Rupert Murdoch

No pardon for her.

Comment Re:Arrest rates (Score 1) 26

by SNRatio (#65183703) Attached to: Research Reveals Data on Which Institutions Are Retraction Hotspots

My point is that the places doing more retracting are likely the ones performing more rigorous checks,

Or those places are not doing rigorous checks at all. They are just responding after international teams of volunteers using digital tools to spot plagiarism, photoshopped data, and other signs of fraudulent research make the problems public.

Comment Re:abd if you are in a noisy enviroment (Score 1) 235

by SNRatio (#64913955) Attached to: Rivian's Chief Software Officer Says In-Car Buttons Are 'An Anomaly'

But here's my point: a touchscreen is going to be there whether we like it or not, because it's cheaper than all the buttons and wires,.... Just like there is no going back to the days of the carburetor, the interior designs of cars are going to have less and less knobs and buttons because they don't want to look antiquated,

Alternatively performance/luxury marques will make a point of having buttons and knobs because they are expensive and retro. They will also find a way to make them a bit unreliable and require lubrication and calibration at the dealer every 20,000 miles.

Comment Re:abd if you are in a noisy enviroment (Score 1) 235

by SNRatio (#64913935) Attached to: Rivian's Chief Software Officer Says In-Car Buttons Are 'An Anomaly'

If you're on the freeway and slam on your brakes to avoid a collision, you also need your hazard lights to warn the guy behind you. Otherwise you’re likely to get rear-ended or worse. And you may have only a second to do that.

If timing is that critical, keep your hands on the wheel and eyes on the road/mirrors, as opposed to finding the hazard light button. Pump the brakes. You can do that a lot faster than the duty cycle for the hazard lights.

Comment Re:Touchscreen is the icon fail of modern UX (Score 2, Interesting) 235

by SNRatio (#64913909) Attached to: Rivian's Chief Software Officer Says In-Car Buttons Are 'An Anomaly'
The primary reason is cost cutting. Buttons are wonderful to have on the steering wheel, but if the wrong connections get glitchy all of a sudden the manufacturer is on the hook for replacing the entire steering wheel + airbag. Compare that to the cost of having a support chatbot tell owners to "speak more clearly" if the voice recognition is glitchy.

Comment Re:There are solutions (Score 1) 230

by SNRatio (#64901681) Attached to: Birth Rate in England and Wales Plunges To Lowest Level Since 1938

None of those things will result in people having more children.

If they did, then people would be having more children in the countries that did them.

The data shows otherwise.

The answer is not in the birth rate of countries that do these things vs countries that don't, it's in how many kids would people have in those countries if they stopped providing those benefits. I'm pretty certain their birth rates would be even lower without them.

Comment Re:The "narrative" (Score 1) 230

by SNRatio (#64901665) Attached to: Birth Rate in England and Wales Plunges To Lowest Level Since 1938
The person you are replying to is a git.

But they were still correct about one thing: delaying the age of first birth does reduce the total fertility rate.

https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fbmjopen.bmj.com%2Fconten...

Have a look at Fig. 2. There is an inverse relationship between the two.

https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fwww.niussp.org%2Ffertili...

Table 1.

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