Blackbox and BBKeys
minimalist type approach, not too resource intensive, looks nice, usually acts nice.
cntrl+shift+numlock to allow you to use the numpad of your keyboard to move the cursor around, 3 button functionality; really cool, i dont have a link handy, but basically hit those three buttons and your numpad becomes a mouse, choose between the 3 mouse buttons by clicking one of the top (nearest to the top of the keyboard) 3 buttons in the numpad, click with 5, click and hold is either 0 or . or something like that... for those apps you still need mouse you still dont have to move your hands off the keyboard...
put these 3 pieces together and you have a relatively good-looking, nice-acting, not-resource intensive, no hand moving between keyboard and mouse for the lazy among us... -donkey