My father in the mid-south had a 3 year long struggle with this infection. It has left him a completely different person (three tumors in his brain). This is a nasty disease that was previously sub-tropical and is making its way into North America. The treatment is really nasty.
Amphotericin B has terrible common side effects and the nurses had a nickname for it that was something like "Ampho the Terrible."
Flucytosine is also used and it has a dramatic effect on the mental state of the patient.
During the time my father was taking these medications he suffered kidney failure, massive weight loss, constant nausea and vomiting, poor impulse control (to the point that it was like he had no filter to stop him from saying or doing anything). I'm very glad my father is still alive but even two years removed he still is suffering the effects of this illness.