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Comment APOE4 (Score 3, Informative) 42

My mother suffered from early onset Alzheimers disease, and died at 73 from complications due to Alzheimers (though she was completely gone as a person well before that). My sisters and I were all part of the AHEAD study (https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fwww.aheadstudy.org%2F) and we all carry the APOE4 gene, but were kicked out because we did not show evidence of amyloid proteins in our head. My sisters continued to get testing privately, but because I have amyloid proteins in my blood, I was admitted to a side study of AHEAD called APEX (https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fwww.actcinfo.org%2Falzheimers-plasma-extension-apex-study%2F). A month ago one of my sisters showed marked decline in cognitive testing, and a subsequent PET scan showed amyloid plaques in her brain. She is 60. They have started her on lacanamab, but from what I read it is a really uncertain treatment, with risks of brain bleeds as a side effect and only the promise of some reduction in the progress of the disease as the best possible outcome.
It's a really scary time.

Comment Re:I came in with low expectations (Score 1) 251

Comment But think of the savings! (Score 5, Insightful) 129

Sure, they're unqualified, but the savings were to die for! And I mean literally to die for anyone who flies in one. MMW, the long term vision at Boeing of cutting corners and saving dimes has finally come home to roost, and I expect it will arrive in the form of some embarrassing congressional testimony for some C-suites followed by an enormous bailout package.

Comment Re:Another antibody treatment that won't work (Score 3, Interesting) 20

This is in fact the concept behind the AHEAD Alzheimers study (https://ancillary-proxy.atarimworker.io?url=https%3A%2F%2Fwww.aheadstudy.org%2F), They intend to find people at significant risk of developing Alzheimers in the future, and treat with medicines like these to prevent amyloid protein build up in the brain. Side note: Anyone can sign up for AHEAD and hopefully help advance Alzheimers research, but not everyone will be accepted (I was weeded out during the early study phases).

Comment More bots, right? (Score 1, Informative) 27

This is going to be nothing more than them using AI to more easily and perhaps more realistically (?) generate bots, perhaps even ones that respond to winks and whatnot. I mean, they say right in TFS that they plan to use it to help generate profiles - the part they're not saying out loud is that it will be for the company to help create profiles for users that don't actually exist.

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