Submission + - Covid-19 infection can reactivate the latent retroviruses in human DNA (phys.org)
He Who Has No Name writes: In a synopsis posted Monday, John Hewitt at Phys.org points out some fairly unsettling implications of an ugly trick by Covid-19 (more formally, SARS-CoV-2) — it wakes up latent viruses that we are born with in our DNA.
A quick version for those not familiar with virology: retroviruses are a subclass of viruses that leave copies of their RNA in the host cell's DNA as part of their replication process, the reverse of the way most viruses replicate (that's where the 'retro' part comes from). Latent, inactive sequences of retroviral DNA make up more than 1% of the human genome. We're literally born with them in our genes.
Now back to Covid's latest trick. From the article:
"Transposable elements, or jumping genes, are now known to be responsible for many human diseases. Keeping them repressed by methylation, RNA binding, or the attentions of the innate immune system is a full-time jump for cells.
Last week, we reviewed the activation of one particular kind of transposable element, the Line-1 retrotransposons, in an ever-expanding host of neurodegenerative conditions. Retrotransposons derive from human endogenous retrovirus (HERVs) but typically have lost their signature long terminal repeat sequences at the beginning and ends of their genes.
On Tuesday, a real zinger was dropped onto the medRxiv preprint server that could potentially explain many of the commonly observed pathogenic features of SARS-CoV-2. The authors provide solid evidence that the SARS-CoV-2 spike protein activates the envelope (ENV) protein encoded by HERV-W in blood cells, which is in turn directly responsible for many pathological features of the disease."
While this is all analysis of preprint research, the evidence and implied results are very much in line with other long-term effects from Covid infection, especially neurocognitive symptoms, known to long haul Covid patients as "brain fog". Given that other research is showing long haul Covid cognitive symptoms are more accurately detected by the cognitive function test specifically used for HIV-Associated Neurocognitive Disorder (HAND) compared to standard function tests, the implication of retroviral elements to the puzzle of PACS (Post-Acute Covid Symptoms, the official term now in use for long haul Covid) is disturbing.
The good news: only about 20-30% of people infected with Covid appear to be susceptible. This is, however, conspicuously in line with other data analysis showing that about 1 in 4 Covid victims has PACS / long haul symptoms after the acute infection stage...
A quick version for those not familiar with virology: retroviruses are a subclass of viruses that leave copies of their RNA in the host cell's DNA as part of their replication process, the reverse of the way most viruses replicate (that's where the 'retro' part comes from). Latent, inactive sequences of retroviral DNA make up more than 1% of the human genome. We're literally born with them in our genes.
Now back to Covid's latest trick. From the article:
"Transposable elements, or jumping genes, are now known to be responsible for many human diseases. Keeping them repressed by methylation, RNA binding, or the attentions of the innate immune system is a full-time jump for cells.
Last week, we reviewed the activation of one particular kind of transposable element, the Line-1 retrotransposons, in an ever-expanding host of neurodegenerative conditions. Retrotransposons derive from human endogenous retrovirus (HERVs) but typically have lost their signature long terminal repeat sequences at the beginning and ends of their genes.
On Tuesday, a real zinger was dropped onto the medRxiv preprint server that could potentially explain many of the commonly observed pathogenic features of SARS-CoV-2. The authors provide solid evidence that the SARS-CoV-2 spike protein activates the envelope (ENV) protein encoded by HERV-W in blood cells, which is in turn directly responsible for many pathological features of the disease."
While this is all analysis of preprint research, the evidence and implied results are very much in line with other long-term effects from Covid infection, especially neurocognitive symptoms, known to long haul Covid patients as "brain fog". Given that other research is showing long haul Covid cognitive symptoms are more accurately detected by the cognitive function test specifically used for HIV-Associated Neurocognitive Disorder (HAND) compared to standard function tests, the implication of retroviral elements to the puzzle of PACS (Post-Acute Covid Symptoms, the official term now in use for long haul Covid) is disturbing.
The good news: only about 20-30% of people infected with Covid appear to be susceptible. This is, however, conspicuously in line with other data analysis showing that about 1 in 4 Covid victims has PACS / long haul symptoms after the acute infection stage...
