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Comment Re:Distance ? Camera resolution ? McFly ? (Score 1) 35

Camera resolution is 2.1 MP @ 1936 x 1096. Distance is nominally 400 km, but the ISS wanders around a lot.

Astrophotography cameras are more about light sensitivity than resolution. The resolution ultimately has much more to do with the optics in front of the camera. This was shot with a Celestron 11 inch Schmidt- Cassegrain telescope, which is native f/10.

As an aside, the best astrophotographers are all large men. Larger telescopes get heavy really quickly. Anyone can buy one of these (an equivalent scope sans mount is about $3k at B&H) but schlepping it around the countryside is another story.

Comment There isn't another choice. (Score 1) 480

AFAICT, there's only one cell surface antigen on the COVID: the spike protein. So mRNA vaccines, traditional vaccines, and natural immune response all target the same antigen.

That having been said, the two mRNA vaccines (should) elicit slightly different antibody profiles. mRNA gets translated into amino acid sequences (proteins) in groups of three sequential nucleotides (these groups are called 'codons'). Since there are four nucleotides, there are 64 possible codons. But these code for only 22 amino acids, so many amino acids have multiple possible codons; the important ones might have five or six mRNA sequences which ultimately produce the same protein.

When the mRNA was sequenced and published (January 2020), Pfizer and Moderna optimized their mRNA approaches for translational efficiency. Humans tend to have lots more transfer RNAs for specific codons for the important amino acids, which tend to be different from what viruses express (this is the origin of the G-C-C G-C-C thing which sort of really does indicate a lab origin for the virus; that codon is optimal for the corresponding AA in humans but doesn't really happen in coronaviruses).

Pfizer and Moderna ultimately wound up with different mRNA sequences for the spike protein, neither of which is the same as the sequence for the original COVID. This is a known fact; Pfizer published their sequence and Moderna's was reverse-engineered.

The variability comes from translational accuracy. Transfer RNAs don't line up on the mRNA with 100% fidelity, so you occasionally get an AA that is different from what is coded. This has the same effect on antibody production as a mutation in the virus. So the two mRNA vaccines produce slightly different antibody profiles from each other and from the virus itself.

Comment Re:false claims (Score 1) 143

Not necessarily. There is stuff added to it. For sure the heme protein to give it the meat flavor.

I had one of the burgers at a picnic a couple of weeks ago. I was pretty surprised at how good it tastes. Not my ideal, but tasty in a different way, sort of like when you get a burger in another country.

Comment The placebo effect is real for every treatment (Score 1) 66

There is a famous example (within medicine) from the treatment of Parkinson's disease, which affects the motor neuron pathways within the brain. A specific symptom, dyskinesia, can be treated by surgical destruction of a very specific part of the brain (globus pallidus; the operation is called pallidotomy).

Because the placebo effect in prior trials for Parkinson's showed placebo effects of ~40%, the clinical trials for pallidotomy were designed to limit those effects as much as possibly to determine real efficacy. That meant that the control group actually went to the OR and got holes drilled in their skulls (but not their brains).

This caused a fairly intensive ethical discussion at the time as there was a real risk for the control group.

Comment Re:otherwise... (Score 1) 56

Have you guys tried to do any kind of hardware development in the last 18 months? It's not just chip shortages, it's every damn thing. It's even hard to source injection molded pieces of plastic without encountering substantial delays. I can't even imagine how much exponentially harder it is to do bleeding-edge tech right now.

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