Alternatives to Mass Dynamics

The biopharmaceutical sector today is characterized by its intricacy, driven by increasing demands for enhanced specificity and safety, the emergence of new treatment classes, and the complexity of disease mechanisms. To navigate this intricate landscape, a profound comprehension of therapeutic dynamics is essential. Advanced modeling and simulation techniques offer a distinctive approach to investigate biological and physicochemical phenomena at the atomic scale. This methodology not only informs physical experimentation but also expedites the drug discovery and development phases. BIOVIA Discovery Studio integrates more than three decades of peer-reviewed research with cutting-edge in silico methodologies, including molecular mechanics, free energy assessments, and biotherapeutics developability, all within a unified framework. By equipping researchers with a comprehensive suite of tools, it facilitates a deeper examination of protein chemistry, thereby accelerating the discovery of both small and large molecule therapeutics, from Target Identification all the way through to Lead Optimization. Ultimately, this synergy of research and technology underscores the vital role of innovative tools in transforming biopharmaceutical advancements.

Genedata Biologics® enhances the development of biotherapeutics, including bispecifics, ADCs, TCRs, CAR-Ts, and AAVs, providing a comprehensive solution for the industry. Recognized as the leading platform in the field, it seamlessly unifies all discovery workflows, allowing researchers to prioritize genuine innovation. By utilizing a pioneering platform that was purposefully created to digitalize the biotherapeutic discovery process, research can be accelerated significantly. The platform simplifies intricate R&D tasks by facilitating the design, tracking, testing, and evaluation of novel biotherapeutic drugs. It is compatible with various formats, such as antibodies, bi- or multi-specifics, ADCs, innovative scaffolds, and therapeutic proteins, as well as engineered therapeutic cell lines like TCRs and CAR-T cells. Functioning as a comprehensive end-to-end data backbone, Genedata Biologics connects all R&D processes, including library design, immunization, selection and panning, molecular biology, screening, protein engineering, expression, purification, and protein analytics, ultimately leading to thorough assessments of candidate developability and manufacturability. This holistic integration ensures that researchers can make informed decisions and push the boundaries of biotherapeutic innovation effectively.

Proteins, which are remarkably complex machines, play a crucial role not only in the biological functions of your body but also in every living organism's processes. They serve as the fundamental units of life. As of now, there are approximately 100 million identified proteins, with discoveries being made regularly. Each protein possesses a distinctive three-dimensional shape that is essential to its functionality and purpose. However, determining a protein's precise structure is often a costly and lengthy endeavor, resulting in an understanding of only a small percentage of the proteins recognized by science. Addressing this growing disparity and developing methods to predict the structures of millions of yet-to-be-discovered proteins could significantly advance our ability to combat diseases, expedite the discovery of new treatments, and potentially unveil the secrets of life's mechanisms. The implications of such advancements could transform both medicine and our understanding of biology.

Grounded in established medical science and transparent systems biology, DARA enhances clinical decision-making and intervention strategies. Collaborating with healthcare providers and relevant stakeholders, we deliver digital solutions that revolutionize health screening and the management of chronic diseases. Our approach facilitates the digital evolution of care delivery through the automation of clinical workflows and the use of predictive analytics, all aligned with leading clinical guidelines and best practices. By offering actionable health insights through tailored predictions of disease risk and potential adverse events, we empower physicians to better connect with their patients. Additionally, we support pharmaceutical development by uncovering pharmacodynamics within intricate biological systems and discovering innovative therapeutic options. Utilizing predictive analytics on comprehensive patient data allows for personalized precision medicine, particularly in managing cardiometabolic diseases to avert severe patient outcomes. With our tools, healthcare can become more proactive and responsive, ultimately leading to improved patient care and health outcomes.

The microbiome plays a significant role in various diseases and health issues. Discover how Kaleido is pioneering a unique method to transform the potential of the microbiome into effective patient solutions. Comprising over 30 trillion microbes, the human microbiome includes a diverse array of organisms such as bacteria, viruses, archaea, and fungi that inhabit both the exterior and interior of the human body. In recent years, there has been a remarkable surge in research focusing on the microbiome's influence on human health, linking it to conditions such as cardiovascular disease, cancer, diabetes, Parkinson’s disease, and allergies. This intricate microbial community has been likened to a "newly discovered organ," highlighting its significance. Just as many human organs command substantial investments for therapies that modify physiology, the microbiome represents a largely unexplored territory in the realm of healthcare. Addressing this frontier could unlock new therapeutic avenues and enhance overall health outcomes.

The process of introducing a new medication to the market, starting from initial development to the final launch, is both time-intensive and heavily regulated, often spanning over a decade or more. Achieving success in this endeavor hinges on the timely availability of precise analytical data, which is essential for making informed decisions during the early stages of development and reducing the likelihood of setbacks later on. Modern drug development primarily follows a systematic approach, with the crucial first step usually being the identification of a biological target to concentrate efforts on. This target identification demands a comprehensive understanding of the characteristics of the candidates, enabling swift and reliable identification of the most promising options. After establishing a biological target, the next significant hurdle is identifying the most advantageous lead molecules, which entails discovering potential drug candidates—these may include small organic compounds or biological constructs with therapeutic capabilities. Thus, the entire journey from concept to market is a complex interplay of scientific insight and strategic decision-making.

The Perfect E-Prescription System (PEPS) is a sophisticated software designed to improve the efficiency and safety in the prescription process. It reduces the chance of errors by allowing healthcare providers to send prescriptions electronically directly to pharmacies. This ensures that patients get their medications quickly. The system has features to manage medication histories, check drug interactions, and accurately dose, which streamlines the prescription lifecycle. Other functionalities include the management and authorization of prescription refills which helps in chronic disease and real-time tracking prescription status which keeps both patients and providers informed. Integration with Perfect Pharmacy Manager allows for a seamless workflow between prescribing medications and dispensing them, improving operational efficiency and patient outcomes.

BIOiSIMTM represents a groundbreaking 'virtual drug development engine' that significantly enhances the drug development sector by effectively identifying drug compounds that are most likely to provide meaningful therapeutic benefits for various diseases or conditions. We provide an array of translational solutions that are tailored to meet the specific needs of your pre-clinical and clinical initiatives. Central to our offerings is the highly validated BIOiSIMTM platform, which supports the development of small molecules, large molecules, and viruses. This innovative platform is underpinned by extensive data derived from thousands of compounds across seven different species, resulting in a level of robustness that is uncommon in the field. Emphasizing human health outcomes, the heart of the platform features a translatability engine that seamlessly converts insights gained from different species. Importantly, the BIOiSIMTM platform can be deployed prior to the initiation of preclinical animal trials, facilitating earlier insights and potentially reducing the costs associated with outsourced experimentation. By integrating these advanced capabilities, we aim to streamline the drug development process and accelerate the journey from discovery to market.

Streamlined surveillance of diverse data sources, seamlessly integrated with a GVP IX compliant signal management platform, can revolutionize your safety data handling. The Evidex platform offers a ready-to-go, GVP-IX compliant signal management solution that simplifies your operations without the hassle of switching between various services. By modernizing your management processes, you can ensure they are audit-proof and efficient. This automation not only helps meet regulatory standards but also enhances the overall value generated for your organization. With automated signal detection, you can identify safety signals from established sources such as ICSR databases, the FDA's Adverse Event Reporting System (FAERS), VigiBase, and clinical trial data. Furthermore, you can incorporate additional data sources, including claims, electronic health records (EHR), and other unstructured information. By aggregating these diverse data pools, you can significantly improve signaling algorithms, streamline validations and assessments, and accelerate responses to pressing drug safety inquiries. Ultimately, this approach transforms how organizations manage and leverage safety data for better outcomes.

We combine clinical and experimental data through machine learning techniques to explore human disease biology and promote the development of precision medicine. Our innovative Contingent AI™ technology comprehends the intricate relationships present in the data, yielding advanced insights. To combat data bias, we refine our machine learning models based on decisions made during the pre-processing and feature engineering phases. We utilize zebrafish, cellular, and various phenotypic animal models to test and confirm in silico predictions through in vivo experiments, along with genetic modifications conducted both in vitro and in vivo to enhance translation. By employing active learning and computer vision on validated models that focus on cardiac, central nervous system, and rare disorders, we swiftly integrate new data into our machine learning frameworks, allowing for continuous improvement and adaptation in our methodologies. This iterative process not only enhances the accuracy of our predictions but also enables us to stay at the forefront of research in precision medicine.

LiveDesign serves as an integrated informatics solution that empowers teams to accelerate their drug discovery initiatives through collaborative design, experimentation, analysis, tracking, and reporting on a unified platform. It allows for the collection of innovative ideas alongside experimental and modeling data seamlessly. Users can develop and archive new virtual compounds within a centralized repository, assess them with sophisticated models, and prioritize the most promising designs. By merging biological data and model outputs from various corporate databases, the platform leverages advanced cheminformatics to provide a comprehensive analysis of all information simultaneously, facilitating quicker compound development. The platform employs cutting-edge physics-based methodologies along with machine learning to enhance prediction accuracy significantly. Teams can collaborate in real-time, regardless of location, enabling them to share concepts, conduct tests, make revisions, and progress chemical series while maintaining a clear record of their work. This not only fosters innovation but also ensures that projects remain organized and efficient throughout the drug discovery process.

3decision® serves as a cloud-based repository for protein structures, focusing on efficient management of structural data and offering sophisticated analytics to support teams involved in the discovery of small molecules and biologics, thereby expediting the process of structure-based drug design. The platform consolidates and standardizes both experimental and computational protein structures sourced from publicly available databases such as RCSB PDB and AlphaFoldDB, in addition to proprietary datasets, and accommodates formats like PDBx/mmCIF and ModelCIF. This comprehensive approach guarantees seamless access to a variety of structural formats including X-Ray, NMR, cryo-EM, and modeled structures, thereby promoting collaboration and bolstering research initiatives. In addition to its storage capabilities, 3decision® enhances each entry with valuable metadata and sequence information, which encompasses details on protein-ligand interactions, antibody annotations, and specifics about binding sites. Equipped with advanced analytical instruments, the platform is capable of pinpointing druggable sites, evaluating off-target risks, and facilitating comparisons of binding sites, which collectively transform extensive structural datasets into practical insights that can drive research forward. Furthermore, its cloud-based architecture fosters enhanced collaboration among research teams, making it easier for scientists to share findings and insights, ultimately leading to more innovative approaches in drug discovery and development.

Our innovative AI solutions are crafted to enhance the capabilities of healthcare professionals at critical stages of the medical process. Whether it's during preventive screenings, early diagnosis, emergency interventions, managing institutional disease outbreaks, or ensuring treatment compliance, we facilitate a smooth optimization of workflows throughout the entire care spectrum. By partnering with esteemed healthcare authorities and leveraging vast amounts of data to inform our algorithms, we ensure that our AI meets the highest global regulatory requirements. Supported by extensive research in data science, our offerings are designed to predict healthcare needs, especially in challenging situations. Our AI solutions are primed for immediate use, adaptable to various settings and situations as necessary. They seamlessly integrate with your existing technology framework and can be customized to work with your preferred devices. We provide straightforward deployment and scaling options while guaranteeing top-tier data security that complies with industry standards. Additionally, our dedicated team is committed to guiding you through every phase of your AI implementation journey, ensuring you feel confident and supported. With our solutions, you can transform your healthcare delivery and improve patient outcomes significantly.

Our innovative AI engine is revolutionizing the drug discovery process, enabling the creation of superior medications at an accelerated pace. The breakthroughs we achieve contribute to the development of medicines more efficiently and effectively. Our portfolio of AI-driven discoveries encompasses entirely owned and collaboratively developed pipeline assets, supported by leading investors in the industry. Atomwise has engineered a cutting-edge machine-learning discovery platform that merges the capabilities of convolutional neural networks with extensive chemical libraries to identify new small-molecule treatments. The key to transforming drug discovery through AI lies in our talented team. We are committed to enhancing our AI platform and leveraging it to revolutionize the discovery of small molecule drugs. It is essential that we confront the most daunting and seemingly insurmountable targets, streamlining the entire drug discovery process to provide developers with increased opportunities for success. Enhanced computational efficiency allows us to screen trillions of compounds virtually, significantly boosting the chances of finding viable solutions. Our impressive model accuracy has successfully addressed the persistent issue of false positives, underscoring the reliability of our approach. Ultimately, our dedication to innovation and excellence sets us apart in the quest for breakthrough therapies.

Zedmed stands out as a comprehensive practice management software solution designed for Australian healthcare professionals. Its strength lies in its ability to centralise and streamline critical workflows across various specialties. General practitioners benefit from functionalities like My Health Record integration and chronic disease management tools, while specialists can leverage features tailored to their specific needs, such as musculoskeletal examination templates. Notably, Zedmed offers both cloud-based and on-premise deployment options, catering to individual practice preferences and data security considerations. This focus on user-centricity and feature customisation positions Zedmed as a powerful tool for enhancing practice efficiency and ultimately improving patient care delivery in Australia.

EpiSoft is a provider of cloud-based medical software that caters to a variety of healthcare fields, such as oncology, mental health, hospital preadmissions, hepatitis, and inflammatory bowel disease. Their comprehensive platform encompasses electronic medical records (EMR), practice management, infusion drug oversight, and portals designed for patient engagement. Notably, EpiSoft's EMR is equipped with features that ensure integration with Medicare, health insurance funds, and the Department of Veterans' Affairs (DVA), which facilitates quicker claim processing. Additionally, it includes a scheduling module specifically designed for intricate care plans, like those involving chemotherapy cycles, along with electronic prescriptions that streamline medication management. The cloud-based nature of their service permits access from any device, while automated SMS and email reminders for appointments significantly reduce the likelihood of no-shows and cancellations. Furthermore, the patient portal seamlessly connects with existing hospital websites and patient administration systems, allowing for the direct capture of validated health histories and demographic information from patients, which ultimately alleviates administrative workloads. This innovative approach not only enhances efficiency but also improves the overall patient experience in healthcare settings.

Discover valuable insights within your data by utilizing the Cortellis™ suite of life science intelligence tools, enabling you to make more informed decisions throughout the entire R&D process. We have alleviated the burden of gathering, integrating, and analyzing data, allowing you to concentrate on the essential choices necessary for expediting your products' market entry. With a unique combination of extensive, high-quality data, fortified by profound domain knowledge, industry insight, and therapeutic expertise, Cortellis reveals crucial insights that facilitate data-driven decisions, ultimately speeding up innovation. Access tailored, actionable responses to your specific inquiries throughout the R&D lifecycle, drawing from the most comprehensive and in-depth intelligence sources available. By incorporating Cortellis into your daily routine, you can significantly enhance the pace of innovation and streamline your workflow. This makes Cortellis not just a tool, but a vital partner in your path to success.

Harnessing RNA sequencing (RNA-seq) data alongside Artificial Intelligence presents both a crucial necessity and a significant opportunity for creating therapies aimed at correcting splicing errors. By leveraging machine learning, we can uncover novel splicing errors and swiftly formulate therapeutic compounds to address them. Our AI platform, SpliceCore, is specifically designed for discovering RNA therapeutics. This cutting-edge technology focuses on analyzing RNA sequencing data with unparalleled efficiency. It can swiftly identify, evaluate, and validate potential drug targets, outpacing traditional methodologies. Central to SpliceCore is our unique repository containing over 5 million potential RNA splicing errors, making it the largest of its kind globally and instrumental for testing any RNA sequencing dataset submitted for analysis. The integration of scalable cloud computing allows us to handle vast quantities of RNA sequencing data in a way that is not only efficient but also cost-effective, significantly speeding up the pace of therapeutic advancements. This innovative approach promises to revolutionize the landscape of RNA therapeutics.

CDD Vault allows you to intuitively organize chemical structures, biological study data, as well as collaborate with external or internal partners via a simple web interface. Start a free trial to see how easy it can be to manage drug discovery data. Tailored for You Affordable Scales with your project team Activity & Registration * Electronic Lab Notebook * Visualization * Inventory * APIs

To expedite innovative breakthroughs and swiftly bring products to market, research and development alongside manufacturing facilities must adapt and modify their processes in real time. Data management should never become a hindrance in this dynamic landscape. The Thermo Scientific™ Nautilus LIMS™ for Dynamic Discovery and R&D Environments, co-developed with clients operating in rapid R&D contexts, offers a highly adaptable and user-friendly system that enhances workflow efficiency, increases throughput, and ensures data accuracy while streamlining administrative tasks, sample tracking, and adherence to regulatory standards. Its automated management of intricate boards and specialized graphics tools simplifies data oversight, allowing even less experienced users to easily identify and monitor processes. Clients are empowered to design workflows, track the life cycles of samples, and automate interactions across various platforms while seamlessly incorporating regulated protocols that conform to good laboratory practices and the 21 CFR Part 11 regulations. This innovative approach not only fosters a more efficient research environment but also encourages collaboration and creativity among teams.

BioNeMo is a cloud service and framework for drug discovery that leverages AI, built on NVIDIA NeMo Megatron, which enables the training and deployment of large-scale biomolecular transformer models. This service features pre-trained large language models (LLMs) and offers comprehensive support for standard file formats related to proteins, DNA, RNA, and chemistry, including data loaders for SMILES molecular structures and FASTA sequences for amino acids and nucleotides. Additionally, users can download the BioNeMo framework for use on their own systems. Among the tools provided are ESM-1 and ProtT5, both transformer-based protein language models that facilitate the generation of learned embeddings for predicting protein structures and properties. Furthermore, the BioNeMo service will include OpenFold, an advanced deep learning model designed for predicting the 3D structures of novel protein sequences, enhancing its utility for researchers in the field. This comprehensive offering positions BioNeMo as a pivotal resource in modern drug discovery efforts.

Harness the capabilities of artificial intelligence to accelerate the transition from laboratory research and experimental findings to the introduction of transformative therapies. Achieve a remarkable increase in research efficiency, potentially improving productivity by as much as 90% by cutting down your literature review time from several months to mere minutes. Eliminate distractions and enhance your search capabilities with a precise and accurate tool that simplifies the navigation of the expanding landscape of scientific publications. This approach not only saves time but also minimizes bias and enhances the likelihood of discovering groundbreaking insights. Delve deeply into the intricacies of disease biology and engage in sophisticated target identification. Causaly's advanced knowledge graph integrates data from countless publications, enabling thorough and objective scientific investigations. Effortlessly explore the intricate biological cause-and-effect dynamics without requiring extensive expertise. Access a comprehensive array of scientific documents and reveal previously overlooked connections. Causaly’s robust AI system processes millions of biomedical articles, facilitating improved decision-making and enhancing research outcomes, ultimately leading to a more informed and innovative scientific community. By utilizing such tools, researchers can significantly transform their methodologies and enhance their contributions to medicine.

LigPlot+ serves as the advanced iteration of the original LIGPLOT software, designed for the automatic creation of 2D diagrams depicting ligand-protein interactions. This tool features a user-friendly Java interface that enables users to edit plots effortlessly through simple mouse click-and-drag actions. Besides the improved interface, LigPlot+ introduces several significant upgrades compared to its predecessor. When analyzing two or more ligand-protein complexes that share notable similarities, the software can automatically present their interaction diagrams either overlayed or side by side, with conserved interactions prominently highlighted for easy identification. Additionally, the LigPlot+ suite integrates an enhanced version of the original DIMPLOT program, which is focused on visualizing protein-protein or domain-domain interactions. Users have the flexibility to choose the specific interface they are interested in, allowing DIMPLOT to produce a detailed diagram that illustrates the residue-residue interactions within that interface. For further clarity in interpretation, the residues from one interface can also be displayed in their sequential order, enhancing the overall usability and functionality of the program. This comprehensive approach makes LigPlot+ a valuable tool for researchers seeking to understand complex molecular interactions more intuitively.

Rare diseases often lack comprehensive research, resulting in insufficient knowledge about essential elements for an effective drug discovery initiative. Our innovative AI platform, Healnet, addresses these issues by scrutinizing vast amounts of drug and disease data to uncover new connections that may lead to potential treatments. Utilizing cutting-edge technologies throughout the discovery and development process allows us to operate multiple phases simultaneously and on a large scale. The conventional approach of focusing on a single disease, target, and drug is overly simplistic, yet it remains the standard for most pharmaceutical companies. The future of drug discovery is driven by AI, characterized by parallel processes and an absence of rigid hypotheses, fundamentally integrating the three core paradigms of drug discovery into a cohesive strategy. This new paradigm not only enhances efficiency but also fosters creativity in developing solutions for complex health challenges.

Founded in 2000, VeraChem LLC aims to enhance the field of computer-aided drug discovery and molecular design by creating advanced computational chemistry techniques that merge innovative basic science with practical applications in research. A key aspect of the company's strategy for product development lies in delivering efficient, high-performance software solutions along with extensive user support. Among the current capabilities of VeraChem's software are predictions for protein-ligand and host-guest binding affinities, rapid and precise calculations of partial atomic charges for drug-like molecules, and the computation of energies and forces utilizing widely-used empirical force fields. Additionally, the software features automatic generation of alternate resonance forms for drug-like compounds, a robust conformational search enabled by the Tork algorithm, and the automatic identification of topological and three-dimensional molecular symmetries. The modular code base of VeraChem’s software packages allows for flexibility and adaptability in meeting diverse research needs, ensuring that users can leverage these tools effectively for their specific applications.

Pharmaceutical companies require extensive genomic data to effectively implement precision medicine initiatives; however, they frequently rely on merely 10% of the available information for their decisions. Genomenon provides access to the complete dataset. Their Prodigy™ Patient Landscapes offer a streamlined and economical solution for natural history research, aiding the creation of therapies for rare diseases by deepening understanding of both retrospective and prospective health data. Utilizing an advanced AI-driven methodology, Genomenon conducts a thorough evaluation of each patient documented in the medical literature in a significantly reduced timeframe. Ensure you capture all relevant insights by exploring every genomic biomarker featured in published studies. Each scientific claim is substantiated by concrete evidence drawn from the medical literature, allowing researchers to uncover all genetic drivers and identify variants recognized as pathogenic in accordance with ACMG clinical standards, thereby enhancing the development process of targeted therapies. By leveraging this comprehensive approach, pharma companies can enhance their research effectiveness and ultimately improve patient outcomes.

AutoDock is a comprehensive suite comprising automated docking tools that aim to forecast the binding interactions of small molecules, like substrates or potential drugs, with a receptor that has a known three-dimensional structure. Over time, this toolset has undergone various modifications and enhancements to introduce new features, alongside the development of multiple computational engines. The software currently includes two main versions: AutoDock 4 and AutoDock Vina, each serving distinct purposes. Recently, the introduction of AutoDock-GPU has provided a significantly accelerated alternative to AutoDock4, achieving docking speeds that are remarkably hundreds of times faster than the original single-CPU version. AutoDock 4 is fundamentally made up of two core components: autodock, which executes the docking of the ligand onto a series of grids that represent the target protein, and autogrid, which is responsible for generating these grids ahead of time. These atomic affinity grids are not just useful for docking purposes; they can also be visualized to aid researchers, particularly organic synthetic chemists, in crafting more effective binding agents. This visualization capability can help streamline the process of drug design significantly.

Eidogen-Sertanty's Target Informatics Platform (TIP) stands out as the pioneering structural informatics system and knowledgebase that empowers researchers to explore the druggable genome through a structural lens. By harnessing the burgeoning wealth of experimental protein structure data, TIP revolutionizes structure-based drug discovery, shifting it from a limited, low-throughput field to a dynamic and data-rich scientific discipline. It is specifically designed to connect the realms of bioinformatics and cheminformatics, providing drug discovery scientists with a repository of insights that are not only unique but also highly synergistic with the information available from traditional bio- and cheminformatics tools. The platform's innovative combination of structural data management with advanced target-to-lead calculation and analytical capabilities significantly enhances every phase of the drug discovery process. With TIP, researchers are better equipped to navigate the complexities of drug development and make informed decisions.

Promethium is an innovative platform for chemistry simulations that harnesses the power of GPUs to significantly speed up the development of drugs and materials by providing more efficient and precise quantum chemistry calculations. Specifically engineered for NVIDIA data center GPUs, such as the A100, it utilizes advanced QC Ware streaming algorithms to deliver remarkable computational speed and impressive power efficiency. This platform can perform density functional theory (DFT) calculations on molecular systems containing as many as 2,000 atoms, enabling researchers to conduct simulations of large molecular structures that traditional CPU-based ab initio methods cannot handle. For example, it can execute a single-point calculation for a protein with 2,056 atoms in just 14 hours using only one GPU. Promethium is equipped with a diverse array of functionalities, including single-point energy computations, geometry optimizations, conformer searches, torsion scans, reaction path optimizations, transition state optimizations, interaction energy evaluations, and relaxed potential energy surface explorations. Its capabilities make it a powerful tool for chemists looking to push the boundaries of molecular modeling and simulation. Ultimately, Promethium is set to transform the landscape of computational chemistry.

Site-Identification by Ligand Competitive Saturation (SILCS) produces three-dimensional maps, known as FragMaps, that illustrate how different chemical functional groups interact with a specific target molecule. By revealing the complexities of molecular dynamics, SILCS offers tools that enhance the optimization of ligand scaffolds through both qualitative and quantitative insights into binding pockets, thereby streamlining the drug design process. This approach employs a range of small molecule probes, each featuring diverse functional groups, alongside explicit solvent modeling and accommodating the flexibility of the target molecule to effectively map protein targets. Furthermore, the technique allows researchers to visualize advantageous interactions with the target macromolecule. With these insights, scientists can strategically design improved ligands with functional groups situated in optimal positions for enhanced efficacy. The innovative nature of SILCS represents a significant advancement in the field of medicinal chemistry.

Dotmatics is the global leader in R&D scientific software that connects science, data, and decision-making. More than 2 million scientists and 10,000 customers trust Dotmatics to accelerate research and help make the world a healthier, cleaner, and safer place to live.

Oncoustics is pioneering the development and application of innovative, patented AI technologies aimed at providing low-cost, non-invasive surveillance, diagnostics, and treatment monitoring for diseases that currently face significant clinical challenges. The company has developed a range of specialized applications focused on various diseases and anatomical structures that are compatible with any point-of-care ultrasound device, allowing physicians, nurses, and technicians to operate them as essential tools in a primary care setting without requiring image analysis. By leveraging AI, Oncoustics transforms affordable point-of-care ultrasound machines into robust diagnostic instruments capable of facilitating quick and economical identification and monitoring of conditions affecting the liver, prostate, kidney, breast, and thyroid. The multidisciplinary team behind Oncoustics consists of professionals with expertise in AI, signal processing, radiology, hepatology, digital health, and ultrasound, ensuring a comprehensive approach to healthcare innovation. The emphasis on cost-effective point-of-care diagnostics and surveillance significantly enhances patient outcomes through timely detection and consistent monitoring, which are crucial for effective disease management and better overall health. As such, Oncoustics is not only addressing immediate healthcare needs but is also setting the stage for a transformation in how we approach disease management in the future.

We are a biotechnology firm in the clinical stage, dedicated to unraveling biological complexities through the integration of cutting-edge innovations spanning biology, chemistry, automation, machine learning, and engineering, all aimed at revolutionizing drug discovery. Our approach allows for enhanced precision in biological manipulation with advanced techniques like CRISPR genome editing and synthetic biology. We also achieve reliable automation for intricate laboratory processes at an unprecedented scale through the use of sophisticated robotics. By employing neural network architectures, we conduct iterative analyses and draw insights from extensive, intricate datasets generated in-house. Furthermore, we are boosting the adaptability of high-performance computing capabilities through cloud-based solutions. Our initiative harnesses new technologies to foster continuous learning cycles around our datasets, establishing us as a next-generation biopharmaceutical enterprise. This is achieved through a harmonious integration of hardware, software, and data, all dedicated to the industrialization of drug discovery. We are transforming the conventional drug discovery pipeline and boast one of the most extensive, diverse, and in-depth pipelines among technology-driven drug discovery companies. Ultimately, our mission is to enhance the efficiency and effectiveness of drug development, paving the way for breakthrough therapies.

Revolutionize the fields of drug discovery and materials research through cutting-edge molecular modeling techniques. Our computational platform, grounded in physics, combines unique solutions for predictive modeling, data analysis, and collaboration, facilitating swift navigation of chemical space. This innovative platform is employed by leading industries globally, serving both drug discovery initiatives and materials science applications across various sectors including aerospace, energy, semiconductors, and electronic displays. It drives our internal drug discovery projects, overseeing processes from target identification through hit discovery and lead optimization. Additionally, it enhances our collaborative research efforts aimed at creating groundbreaking medicines to address significant public health challenges. With a dedicated team of over 150 Ph.D. scientists, we commit substantial resources to research and development. Our contributions to the scientific community include more than 400 peer-reviewed publications that validate the efficacy of our physics-based methodologies, and we remain at the forefront of advancing computational modeling techniques. We are steadfast in our mission to innovate and expand the possibilities within our field.

emr4MD, with its version 9.10, is an ONC Certified HIT 2015 Edition solution that serves as a dynamic, web-based electronic health record (EHR) software, a component of MedNet Medical Solutions' cost-effective EMR/EHR and Medical Billing offerings, which seamlessly unifies both administrative and clinical operations into a single system for enhanced and consistent patient care. We tailor your templates to fit your specific clinical requirements while aiding physicians in achieving efficient documentation. Our belief is that an EMR should transcend being just a tool for “meaningful” documentation; it should actively facilitate disease management at the point of care. To address this need, we have developed a powerful “Disease Management Engine” that optimizes patient outcomes. This ensures that healthcare providers are well-equipped to manage patient health proactively and effectively.

AI-powered drug discovery is a proven technology. Cerella extracts hidden insights from your drug discovery data to reveal the best compounds and most valuable experiment for your project. It can make confident predictions by accurately filling in the missing values. This is especially useful for expensive downstream experiments, which are impossible to predict using other methods. This allows you to do more with sparse and limited data sets.

Rimidi empowers healthcare practices to successfully implement a remote patient monitoring (RPM) program, whether your team conducts the monitoring independently or collaborates with us for our monitoring services. The Rimidi platform supports chronic care management (CCM) across your patient population, integrating seamlessly with RPM initiatives and other chronic disease management efforts, all within the existing electronic health record (EHR) workflow. Additionally, Rimidi's adaptable decision support engine is designed to align with national practice guidelines, client-specific protocols, remote monitoring workflows, referral management, and even clinical trial recruitment, among other functions. Patient feedback is readily accessible within your current workflow, allowing for the tracking of trends over time and easy incorporation into clinical documentation. Furthermore, decision support notifications and reminders can be tailored and generated based on RPM data collected from connected devices, enhancing overall patient care management. This comprehensive approach not only streamlines processes but also significantly improves the quality of care delivered to patients.

DNAnexus Apollo™ enhances the efficiency of precision drug discovery by fostering collaboration that extracts valuable insights from omics data. The process of precision drug discovery involves the aggregation and examination of vast amounts of omics and clinical information. These extensive datasets serve as valuable assets; however, many traditional and custom-built informatics tools struggle to manage their intricacies and scale. Additionally, the effectiveness of precision medicine initiatives can be hindered by fragmented data sources, inadequate collaboration tools, and the challenges posed by complex, evolving regulatory and security demands. By enabling scientists and clinicians to jointly investigate and interpret omics and clinical data within a unified framework, DNAnexus Apollo™ bolsters precision drug discovery efforts. This platform, which is powered by a resilient and scalable cloud infrastructure, facilitates the seamless and secure sharing of data, tools, and analyses among peers and collaborators, regardless of whether they are nearby or across the globe. Ultimately, Apollo not only streamlines the data-sharing process but also enhances the overall collaborative experience in the pursuit of innovative drug discoveries.

We have established ourselves as frontrunners in the fields of ADMET property prediction, physiologically-based pharmacokinetics (PBPK) modeling, pharmacometrics, and quantitative systems pharmacology/toxicology, a status achieved through the achievements our clients have experienced while partnering with us. Leveraging over two decades of expertise, our skilled team excels at transforming complex scientific concepts into accessible software solutions, while also offering specialized consulting services that bolster drug discovery, clinical development research, and regulatory submission processes. Our dedication to client success drives our continuous improvement and innovation in these critical areas.

AviTracks-DM is an online clinical decision support system specifically designed for the management of patients with various chronic conditions. It features an automated workflow along with real-time integration of electronic medical records (EMR) and laboratory interfaces, making it an essential tool for hospitals, health systems, and large specialty clinics that cater to high-acuity patients, where timely information is crucial for improving patient outcomes. This system simplifies the process of enhancing care quality for high-risk individuals, facilitates smoother information exchange, and allows for the management of a greater number of patients without necessitating an increase in staffing. AviTracks-DM continuously updates the status of each patient, covering aspects such as pending lab results, labs that require review, critical alerts, and follow-up reminders. Additionally, it offers built-in and customizable reports to generate the necessary documentation for compliance with quality initiatives and pay-for-performance standards, ultimately contributing to more effective patient management. With its comprehensive capabilities, AviTracks-DM stands out as a valuable asset in the healthcare landscape, ensuring that providers are always equipped with the most current data.

Eprovion is an advanced provider management solution tailored for payers that streamlines contract workflows across different types of providers. This system seamlessly integrates with claims processing platforms, ensuring precise contract loading while providing claims-based profiles for providers. Future iterations of eprovion are set to introduce features like claims issue resolution, enhanced business intelligence, and comprehensive disease management capabilities. As a web-based enterprise-class system, it guarantees scalability, security, robustness, and exceptional performance along with high availability. Eprovion effectively manages the entire contract lifecycle, from the initial preparation for negotiations using detailed provider profiles to scheduling negotiation timelines, overseeing contracts throughout their duration, and handling renewals or terminations. All these functionalities are housed within a user-friendly interface, complemented by strong MS-Office integration. Users can create reusable contract templates, while the system also supports annotations, versioning, and batch processing of contracts, making it an invaluable tool for efficient contract management. This comprehensive approach not only enhances administrative efficiency but also facilitates better decision-making for payers.

The emergency department stands out in its operations, and consequently, its documentation solution must reflect that distinctiveness. EV is currently the most widely utilized emergency department information system (EDIS) across the United States, driven by robust clinical expertise and a user-friendly workflow tailored specifically for emergency care scenarios. Developed and continuously refined by a dedicated team of emergency medical professionals at The T System, the clinical content provided by EV is recognized as the benchmark in emergency medicine. It is meticulously crafted to accommodate the diverse range of conditions and varying levels of urgency that present in emergency departments, equipping healthcare providers with vital information to effectively assess, treat, and diagnose patients swiftly. Furthermore, EV is consistently updated to incorporate the latest regulatory changes, respond to disease outbreaks, and adjust to evolving clinical guidelines. By integrating seamlessly with your enterprise electronic health record (EHR), The T System’s EDIS can enhance your emergency department's operational efficiency, throughput, and financial performance. This solution not only streamlines workflows but also empowers clinicians to deliver high-quality care in a fast-paced environment.

Digital Care Made Human™. Omada® enables individuals to reach their health aspirations through enduring lifestyle modifications. Our all-encompassing digital care ensures that engaging in various programs is simple, as we provide your workforce with round-the-clock, tailored support to meet their unique health requirements. Prediabetes Prevention: An alarming 1 in 3 Americans is affected by prediabetes. With Omada’s Prevention program, participants can expect a 30% reduction in the risk of Type 2 Diabetes and a 13% decrease in heart disease risk. On average, those who complete the program shed around 4-5% of their body weight and maintain this loss over time. Diabetes Management: A concerning 46% of diabetes patients fail to achieve proper glycemic control (A1C < 7%). In Omada’s Diabetes program, 92% of participants express satisfaction, and those who were not meeting their goals saw an A1C reduction of over 1%. Additionally, with Hypertension affecting 46% of the US population, our programs are designed to address this significant health challenge effectively. Our commitment to ongoing support ensures that individuals can take charge of their health journey with confidence.

Acuity Advanced Care™ is a flexible on-premise population health platform tailored to meet the varied requirements of case, utilization, disease, and overall population health management initiatives. This system empowers organizations by granting them complete control over their environment while allowing for customization to cater to each entity's distinctive care strategies. Impressively, over 90% of Acuity Advanced clients hold either NCQA or URAC accreditation, or both. With Acuity Advanced Care, users benefit from the inherent flexibility that an on-premise solution provides, along with comprehensive database access. The on-premise setup enables organizations to dictate the location of their data storage. Those clients who possess skilled IT teams are capable of handling the configuration, security, and upkeep of intricate systems independently. Chordline Health stands out as a premier software provider focused on assisting health plans, TPAs, ACOs, and various risk-bearing entities. The skilled team at Chordline, composed of US-based clinicians and developers, is celebrated for its unparalleled expertise in managed care and exceptional customer service, ensuring that clients receive top-tier support and solutions for their healthcare needs.

Effectively overseeing patient care requires a balanced mix of clinical expertise and technological tools. In a field often characterized by high labor demands, these tools should not only facilitate and improve care management processes but also enhance the financial health of the organization. AveCare offers a comprehensive solution that integrates care management functions—including care management (CM), disease management (DM), and utilization management (UM)—streamlining workflows and providing robust management capabilities at a competitive price point, enabling organizations to maximize both clinical and financial resources while elevating the quality of care and patient outcomes. The platform allows for the exchange of data from a variety of sources such as eligibility, claims, pharmacy, diagnostic tests, lab results, predictive analytics, decision support systems, and electronic faxing. Designed for integration, it seamlessly combines case management, disease management education, and utilization management functions into one cohesive system. Users can access a centralized view of all relevant CM, DM, and UM activities related to each patient, ensuring that care is coordinated and informed by comprehensive data. This holistic approach not only streamlines operations but also fosters better communication among healthcare providers.