ESMFold2 Description
ESMFold2 builds upon its predecessor, ESMFold, by establishing a new benchmark in single-sequence structure prediction and facilitating the creation of novel functional proteins via exploration of the latent space within the ESMC model. This advanced model is capable of forecasting high-resolution, all-atom 3D structures of biomolecular complexes straight from the amino acid sequence, and it allows for the incorporation of multiple sequence alignments to improve accuracy on difficult targets. Tailored for predicting structures through both sequence and structure modalities, it employs ESM representations that drive a series of looped folding layers while a diffusion model translates pairwise representations into atomic-resolution outcomes. ESMFold2 excels in predicting protein structures from amino acid sequences, providing detailed structural data, including precise all-atom coordinates for both backbone and side chains, along with confidence metrics and optional distogram predictions for in-depth structural evaluation. Furthermore, its innovative approach enhances the understanding of protein folding dynamics and functional implications, making it a valuable tool for researchers in the field.
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FLUX 3
FLUX 3 is an advanced multimodal foundation model that integrates learning from images, video, and audio all within a cohesive framework, effectively modeling how objects connect, how movements occur, and how events produce sound. Utilizing the Self-Flow methodology, it harmonizes the generation and comprehension of multiple modalities in a singular architecture, ensuring that each modality influences the others—sound corresponds to impact, motion adheres to physical laws, and future occurrences are informed by past events. This model is capable of blending modalities, allowing for the simultaneous generation of images, video, and authentic audio based on text prompts or references such as visual and auditory inputs. Its video functionalities are extensive, featuring text-to-video capabilities, image-driven video animation, video transformation, generative continuation of video and audio, controlled transitions using keyframes, multilingual dialogue support, animated text design, and the ability to deliver various styles and aspect ratios, alongside the capacity for agentic chaining into intricate, longer multi-shot sequences. Additionally, FLUX 3 represents a significant leap forward in the field of multimodal AI, offering unprecedented flexibility and creativity in generating rich, interactive content.
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NVIDIA BioNeMo
BioNeMo is a cloud service and framework for drug discovery that leverages AI, built on NVIDIA NeMo Megatron, which enables the training and deployment of large-scale biomolecular transformer models. This service features pre-trained large language models (LLMs) and offers comprehensive support for standard file formats related to proteins, DNA, RNA, and chemistry, including data loaders for SMILES molecular structures and FASTA sequences for amino acids and nucleotides. Additionally, users can download the BioNeMo framework for use on their own systems. Among the tools provided are ESM-1 and ProtT5, both transformer-based protein language models that facilitate the generation of learned embeddings for predicting protein structures and properties. Furthermore, the BioNeMo service will include OpenFold, an advanced deep learning model designed for predicting the 3D structures of novel protein sequences, enhancing its utility for researchers in the field. This comprehensive offering positions BioNeMo as a pivotal resource in modern drug discovery efforts.
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Pricing
Pricing Starts At:
Free
Free Version:
Yes
Company Details
Company:
Biohub
Year Founded:
2016
Headquarters:
United States
Website:
biohub.ai/models/esmfold2
Media
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Product Details
Platforms
Web-Based
Types of Training
Training Docs
Customer Support
Online Support
ESMFold2 Features and Options
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