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Description

ESMFold2 builds upon its predecessor, ESMFold, by establishing a new benchmark in single-sequence structure prediction and facilitating the creation of novel functional proteins via exploration of the latent space within the ESMC model. This advanced model is capable of forecasting high-resolution, all-atom 3D structures of biomolecular complexes straight from the amino acid sequence, and it allows for the incorporation of multiple sequence alignments to improve accuracy on difficult targets. Tailored for predicting structures through both sequence and structure modalities, it employs ESM representations that drive a series of looped folding layers while a diffusion model translates pairwise representations into atomic-resolution outcomes. ESMFold2 excels in predicting protein structures from amino acid sequences, providing detailed structural data, including precise all-atom coordinates for both backbone and side chains, along with confidence metrics and optional distogram predictions for in-depth structural evaluation. Furthermore, its innovative approach enhances the understanding of protein folding dynamics and functional implications, making it a valuable tool for researchers in the field.

Description

Microsoft has introduced Muse, an innovative generative AI model poised to transform the way gameplay concepts are developed. In partnership with Ninja Theory, this World and Human Action Model (WHAM) draws training data from the game Bleeding Edge, granting it a profound grasp of 3D game landscapes, including the intricacies of physics and player interactions. This capability allows Muse to generate varied and coherent gameplay sequences, which can enhance the creative process for developers. Additionally, the AI is capable of creating game visuals and anticipating controller actions, streamlining prototyping and artistic exploration in game design. By leveraging an analysis of over 1 billion images and actions, Muse showcases its potential not only for game creation but also for game preservation, as it can recreate classic titles for contemporary gaming platforms. Despite being in its initial phases, with output currently limited to a resolution of 300×180 pixels, Muse signifies a pivotal step forward in harnessing AI to support game development, with the goal of amplifying human creativity rather than supplanting it. As Muse evolves, it may open up new avenues for both game innovation and the revival of beloved gaming classics.

API Access

Has API Yes 

API Access

Has API No 

Screenshots View All

Screenshots View All

Integrations

Biohub Yes 
Claude Fable 5.1 No 
Claude Mythos 5 No 
Claude Opus 5 No 
Claude Opus 5.5 No 
GPT-5.4 mini No 
GPT-5.4 nano No 
GPT-5.6 Sol Ultrafast No 
GPT-5.6 Terra No 
GPT-6 Astra No 
GPT-6 Luna No 
GPT-6 Sol No 
Hugging Face No 
Microsoft Foundry No 
Python Yes 
Tincan No 

Integrations

Biohub No 
Claude Fable 5.1 Yes 
Claude Mythos 5 Yes 
Claude Opus 5 Yes 
Claude Opus 5.5 Yes 
GPT-5.4 mini Yes 
GPT-5.4 nano Yes 
GPT-5.6 Sol Ultrafast Yes 
GPT-5.6 Terra Yes 
GPT-6 Astra Yes 
GPT-6 Luna Yes 
GPT-6 Sol Yes 
Hugging Face Yes 
Microsoft Foundry Yes 
Python No 
Tincan Yes 

Pricing Details

Free
Free Trial No 
Free Version Yes 

Pricing Details

No price information available.
Free Trial No 
Free Version No 

Deployment

Web-Based Yes 
On-Premises No 
iPhone App No 
iPad App No 
Android App No 
Windows No 
Mac No 
Linux No 
Chromebook No 

Deployment

Web-Based Yes 
On-Premises No 
iPhone App No 
iPad App No 
Android App No 
Windows No 
Mac No 
Linux No 
Chromebook No 

Customer Support

Business Hours No 
Live Rep (24/7) No 
Online Support Yes 

Customer Support

Business Hours Yes 
Live Rep (24/7) No 
Online Support Yes 

Types of Training

Training Docs Yes 
Webinars No 
Live Training (Online) No 
In Person No 

Types of Training

Training Docs Yes 
Webinars Yes 
Live Training (Online) Yes 
In Person Yes 

Vendor Details

Company Name

Biohub

Founded

2016

Country

United States

Website

biohub.ai/models/esmfold2

Vendor Details

Company Name

Microsoft

Founded

1975

Country

United States

Website

microsoft.com

Product Features

Product Features

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