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Description

A closed-loop universal multivariable optimizer is designed to enhance both the performance and quality of Model Predictive Control (MPC) systems. This optimizer utilizes data from Excel files sourced from Dynamic Matrix Control (DMC) by Aspen Tech, Robust Model Predictive Control Technology (RMPCT) from Honeywell, or Predict Pro from Emerson to develop and refine accurate models for various multivariable-controller variable (MV-CV) pairs. This innovative optimization technology eliminates the need for step tests typically required by Aspen Tech and Honeywell, operating entirely within the time domain while remaining user-friendly, compact, and efficient. Given that Model Predictive Controls (MPC) can encompass tens or even hundreds of dynamic models, the possibility of incorrect models is a significant concern. The presence of inaccurate dynamic models in MPCs leads to bias, which is identified as model prediction error, manifesting as discrepancies between predicted signals and actual measurements from sensors. COLUMBO serves as a powerful tool to enhance the accuracy of Model Predictive Control (MPC) models, effectively utilizing either open-loop or fully closed-loop data to ensure optimal performance. By addressing the potential for errors in dynamic models, COLUMBO aims to significantly improve overall control system effectiveness.

Description

ESMFold2 builds upon its predecessor, ESMFold, by establishing a new benchmark in single-sequence structure prediction and facilitating the creation of novel functional proteins via exploration of the latent space within the ESMC model. This advanced model is capable of forecasting high-resolution, all-atom 3D structures of biomolecular complexes straight from the amino acid sequence, and it allows for the incorporation of multiple sequence alignments to improve accuracy on difficult targets. Tailored for predicting structures through both sequence and structure modalities, it employs ESM representations that drive a series of looped folding layers while a diffusion model translates pairwise representations into atomic-resolution outcomes. ESMFold2 excels in predicting protein structures from amino acid sequences, providing detailed structural data, including precise all-atom coordinates for both backbone and side chains, along with confidence metrics and optional distogram predictions for in-depth structural evaluation. Furthermore, its innovative approach enhances the understanding of protein folding dynamics and functional implications, making it a valuable tool for researchers in the field.

API Access

Has API No 

API Access

Has API Yes 

Screenshots View All

Screenshots View All

Integrations

Aspen DMC3 Yes 
Biohub No 
Microsoft Excel Yes 
Python No 

Integrations

Aspen DMC3 No 
Biohub Yes 
Microsoft Excel No 
Python Yes 

Pricing Details

No price information available.
Free Trial Yes 
Free Version No 

Pricing Details

Free
Free Trial No 
Free Version Yes 

Deployment

Web-Based Yes 
On-Premises No 
iPhone App No 
iPad App No 
Android App No 
Windows No 
Mac No 
Linux No 
Chromebook No 

Deployment

Web-Based Yes 
On-Premises No 
iPhone App No 
iPad App No 
Android App No 
Windows No 
Mac No 
Linux No 
Chromebook No 

Customer Support

Business Hours Yes 
Live Rep (24/7) No 
Online Support Yes 

Customer Support

Business Hours No 
Live Rep (24/7) No 
Online Support Yes 

Types of Training

Training Docs Yes 
Webinars No 
Live Training (Online) Yes 
In Person Yes 

Types of Training

Training Docs Yes 
Webinars No 
Live Training (Online) No 
In Person No 

Vendor Details

Company Name

PiControl Solutions

Country

United States

Website

www.picontrolsolutions.com/products/columbo/

Vendor Details

Company Name

Biohub

Founded

2016

Country

United States

Website

biohub.ai/models/esmfold2

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