To begin your journey with the Binance Smart Chain, the initial step is to acquire a wallet that is compatible with Binance's BEP20 tokens, which are designed similarly to Ethereum's ERC20 tokens. Next, link your Metamask wallet to the Binance Smart Chain network, ensuring you have a minimum of 0.1 BNB in your wallet to facilitate transactions. This will allow you to seamlessly interact with various decentralized applications on the platform.