ZSegment is an innovative cloud-native interface engine developed by 314e Corporation, tailored to effortlessly link and unify clinical, financial, and administrative systems within healthcare organizations. With an impressive array of over 300 components, it facilitates real-time metrics grounded in open telemetry standards and is built on a Kubernetes-native framework utilizing Apache Camel to provide scalability, adaptability, and user-friendly customization options including version control (Git) and native custom schema support for HL7 v2, FHIR, X12, and CCD. Additionally, it boasts visual tools for message routing, Groovy scripting for data transformations, and secure message delivery through various protocols such as File, FTP, HTTP(S), and TCP. The platform also includes features like message indexing, tracing, editing/resubmission capabilities, and the ability to define custom jobs for data hygiene and operational oversight. As a modern alternative to traditional on-premise interface engines like Mirth Connect, ZSegment helps organizations reduce hardware procurement expenses and high licensing fees, making it a cost-effective solution for enhancing interoperability in healthcare systems. Furthermore, its cloud-native design means that organizations can quickly adapt to evolving demands without the constraints of legacy infrastructure.