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Description
Cufflinks is a software tool that compiles transcripts, estimates their levels of abundance, and evaluates differential expression and regulation in RNA-Seq datasets. By accepting aligned RNA-Seq reads, it organizes these alignments into a streamlined representation of transcripts. The software then assesses the relative abundances of these transcripts based on the number of supporting reads, while also factoring in potential biases from library preparation methods. Initially created through a collaboration with the Laboratory for Mathematical and Computational Biology, Cufflinks aims to simplify the installation process by offering several binary packages that alleviate the often cumbersome task of building the software from source, which necessitates the installation of various libraries. This toolset encompasses multiple utilities tailored for analyzing RNA-Seq experiments, with some functionalities available independently and others designed to fit into a more comprehensive workflow. Overall, Cufflinks serves as a vital resource for researchers in the field of genomics, enhancing their ability to interpret RNA-Seq data effectively.
Description
Created within the Data Sciences Platform at the Broad Institute, this comprehensive toolkit provides an extensive array of features primarily aimed at variant discovery and genotyping. With its robust processing engine and high-performance computing capabilities, it is equipped to manage projects of any magnitude. The GATK has established itself as the industry benchmark for detecting SNPs and indels in both germline DNA and RNA sequencing data. Its functionalities are now broadening to encompass somatic short variant detection as well as addressing copy number variations (CNV) and structural variations (SV). Besides the core variant callers, the GATK incorporates numerous utilities for executing associated tasks, including the processing and quality assurance of high-throughput sequencing data, and it comes bundled with the well-known Picard toolkit. Originally designed for exome and whole genome data generated via Illumina sequencing technology, these tools are versatile enough to be modified for use with various other technologies and study designs. As research evolves, the adaptability of the GATK ensures it remains relevant in diverse genomic investigations.
API Access
Has API
No
API Access
Has API
No
Integrations
Docker
No
Pricing Details
Free
Free Trial
No
Free Version
Yes
Pricing Details
Free
Free Trial
No
Free Version
Yes
Deployment
Web-Based
No
On-Premises
No
iPhone App
No
iPad App
No
Android App
No
Windows
Yes
Mac
Yes
Linux
Yes
Chromebook
No
Deployment
Web-Based
Yes
On-Premises
No
iPhone App
No
iPad App
No
Android App
No
Windows
Yes
Mac
Yes
Linux
Yes
Chromebook
No
Customer Support
Business Hours
No
Live Rep (24/7)
No
Online Support
Yes
Customer Support
Business Hours
No
Live Rep (24/7)
No
Online Support
Yes
Types of Training
Training Docs
Yes
Webinars
No
Live Training (Online)
No
In Person
No
Types of Training
Training Docs
Yes
Webinars
Yes
Live Training (Online)
No
In Person
No
Vendor Details
Company Name
Cole Trapnell
Founded
2017
Country
United States
Website
cole-trapnell-lab.github.io/cufflinks/
Vendor Details
Company Name
Broad Institute
Country
United States
Website
gatk.broadinstitute.org/hc/